QRFPR — 58 ClinVar variants
All ClinVar germline QRFPR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
58 Uncertain significance
Full QRFPR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- QRFPR p.Ile296Thr Uncertain significance Multiple submitters
- QRFPR p.Ala128Thr Uncertain significance Single submitter
- QRFPR p.Ala315Val Uncertain significance Single submitter
- QRFPR p.Arg13Trp Uncertain significance Single submitter
- QRFPR p.Arg160Gln Uncertain significance Single submitter
- QRFPR p.Arg161Thr Uncertain significance Single submitter
- QRFPR p.Arg22Gln Uncertain significance Single submitter
- QRFPR p.Asn110Asp Uncertain significance Single submitter
- QRFPR p.Asn19Ser Uncertain significance Single submitter
- QRFPR p.Asn324Ser Uncertain significance Single submitter
- QRFPR p.Asn328Ile Uncertain significance Single submitter
- QRFPR p.Asn424Ile Uncertain significance Single submitter
- QRFPR p.Asp191Gly Uncertain significance Single submitter
- QRFPR p.Cys85Arg Uncertain significance Single submitter
- QRFPR p.Gln211Glu Uncertain significance Single submitter
- QRFPR p.Glu23Gln Uncertain significance Single submitter
- QRFPR p.Glu389Asp Uncertain significance Single submitter
- QRFPR p.Glu39Gln Uncertain significance Single submitter
- QRFPR p.Glu406Val Uncertain significance Single submitter
- QRFPR p.Gly394Asp Uncertain significance Single submitter
- QRFPR p.Gly430Arg Uncertain significance Single submitter
- QRFPR p.His182Gln Uncertain significance Single submitter
- QRFPR p.His198Asn Uncertain significance Single submitter
- QRFPR p.His413Arg Uncertain significance Single submitter
- QRFPR p.Ile107Val Uncertain significance Single submitter
- QRFPR p.Ile117Val Uncertain significance Single submitter
- QRFPR p.Ile232Ser Uncertain significance Single submitter
- QRFPR p.Ile367Asn Uncertain significance Single submitter
- QRFPR p.Leu186Ile Uncertain significance Single submitter
- QRFPR p.Leu378Phe Uncertain significance Single submitter
- QRFPR p.Lys303Glu Uncertain significance Single submitter
- QRFPR p.Lys407Asn Uncertain significance Single submitter
- QRFPR p.Lys45Thr Uncertain significance Single submitter
- QRFPR p.Lys74Asn Uncertain significance Single submitter
- QRFPR p.Met136Val Uncertain significance Single submitter
- QRFPR p.Met165Val Uncertain significance Single submitter
- QRFPR p.Met180Thr Uncertain significance Single submitter
- QRFPR p.Met274Val Uncertain significance Single submitter
- QRFPR p.Met369Val Uncertain significance Single submitter
- QRFPR p.Phe83Cys Uncertain significance Single submitter
- QRFPR p.Ser12Pro Uncertain significance Single submitter
- QRFPR p.Thr277Ile Uncertain significance Single submitter
- QRFPR p.Tyr234Cys Uncertain significance Single submitter
- QRFPR p.Val121Leu Uncertain significance Single submitter
- QRFPR p.Val176Ile Uncertain significance Single submitter
- QRFPR p.Val183Met Uncertain significance Single submitter
- QRFPR p.Val352Ala Uncertain significance Single submitter
- QRFPR p.Val352Ile Uncertain significance Single submitter
- QRFPR p.Val53Met Uncertain significance Single submitter
- QRFPR p.Val79Phe Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All QRFPR variants
Uncertain significance 58
- p.Ile296Thr Multiple submitters ⚠
- p.Ala128Thr Single submitter ⚠
- p.Ala315Val Single submitter ⚠
- p.Arg13Trp Single submitter ⚠
- p.Arg160Gln Single submitter ⚠
- p.Arg161Thr Single submitter ⚠
- p.Arg16Pro Single submitter
- p.Arg22Gln Single submitter ⚠
- p.Asn110Asp Single submitter ⚠
- p.Asn19Ser Single submitter ⚠
- p.Asn324Ser Single submitter ⚠
- p.Asn328Ile Single submitter ⚠
- p.Asn424Ile Single submitter ⚠
- p.Asp191Gly Single submitter ⚠
- p.Cys85Arg Single submitter ⚠
- p.Gln211Glu Single submitter ⚠
- p.Glu23Gln Single submitter ⚠
- p.Glu260Val Single submitter
- p.Glu389Asp Single submitter ⚠
- p.Glu39Gln Single submitter ⚠
- p.Glu406Val Single submitter ⚠
- p.Gly394Asp Single submitter ⚠
- p.Gly430Arg Single submitter ⚠
- p.His182Gln Single submitter ⚠
- p.His198Asn Single submitter ⚠
- p.His413Arg Single submitter ⚠
- p.Ile107Val Single submitter ⚠
- p.Ile117Val Single submitter ⚠
- p.Ile218Thr Single submitter
- p.Ile232Ser Single submitter ⚠
- p.Ile237Thr Single submitter ⚠
- p.Ile256Ser Single submitter
- p.Ile367Asn Single submitter ⚠
- p.Leu186Ile Single submitter ⚠
- p.Leu34Pro Single submitter
- p.Leu378Phe Single submitter ⚠
- p.Lys303Glu Single submitter ⚠
- p.Lys407Asn Single submitter ⚠
- p.Lys45Thr Single submitter ⚠
- p.Lys74Asn Single submitter ⚠
- p.Met136Val Single submitter ⚠
- p.Met165Val Single submitter ⚠
- p.Met180Thr Single submitter ⚠
- p.Met274Val Single submitter ⚠
- p.Met369Val Single submitter ⚠
- p.Phe83Cys Single submitter ⚠
- p.Pro226Ser Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Ser12Pro Single submitter ⚠
- p.Thr277Ile Single submitter ⚠
- p.Tyr234Cys Single submitter ⚠
- p.Val121Leu Single submitter ⚠
- p.Val176Ile Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val352Ala Single submitter ⚠
- p.Val352Ile Single submitter ⚠
- p.Val53Met Single submitter ⚠
- p.Val79Phe Single submitter ⚠