RAB14 — 13 ClinVar variants
All ClinVar germline RAB14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
2 Benign · 1 Likely benign · 10 Uncertain significance
Full RAB14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAB14 p.Ala126Thr Uncertain significance Single submitter
- RAB14 p.Arg201Gln Uncertain significance Single submitter
- RAB14 p.Cys215Ser Uncertain significance Single submitter
-
RAB14 p.Gln63His
Uncertain significance
Single submitter
RAB14-related disorder
- RAB14 p.Pro197Leu Uncertain significance Single submitter
- RAB14 p.Thr203Ile Uncertain significance Single submitter
- RAB14 p.Thr67Met Uncertain significance Single submitter
- RAB14 p.Tyr173Cys Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All RAB14 variants
Likely benign 1
- c.439+15_439+16del Single submitter
Uncertain significance 10
- p.Ala126Thr Single submitter ⚠
- p.Ala75Ser Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Cys215Ser Single submitter ⚠
- p.Gln63His Single submitter RAB14-related disorder ⚠
- p.Leu102fs Single submitter
- p.Pro197Leu Single submitter ⚠
- p.Thr203Ile Single submitter ⚠
- p.Thr67Met Single submitter ⚠
- p.Tyr173Cys Single submitter ⚠