RAB29 — 31 ClinVar variants
All ClinVar germline RAB29 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Benign · 1 Likely benign · 29 Uncertain significance
Full RAB29 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAB29 p.Ala17Thr Uncertain significance Single submitter
- RAB29 p.Ala45Ser Uncertain significance Single submitter
- RAB29 p.Ala65Ser Uncertain significance Single submitter
- RAB29 p.Arg136Gly Uncertain significance Single submitter
- RAB29 p.Arg141Gln Uncertain significance Single submitter
- RAB29 p.Arg141Gly Uncertain significance Single submitter
- RAB29 p.Arg58Gln Uncertain significance Single submitter
- RAB29 p.Arg69Cys Uncertain significance Single submitter
- RAB29 p.Asn114Ser Uncertain significance Single submitter
- RAB29 p.Asn176Ile Uncertain significance Single submitter
- RAB29 p.Asn92Ser Uncertain significance Single submitter
- RAB29 p.Asp180Val Uncertain significance Single submitter
- RAB29 p.Asp53Ala Uncertain significance Single submitter
- RAB29 p.Gly147Ser Uncertain significance Single submitter
- RAB29 p.Gly2Cys Uncertain significance Single submitter
- RAB29 p.His35Arg Uncertain significance Single submitter
- RAB29 p.Leu23Val Uncertain significance Single submitter
- RAB29 p.Met182Thr Uncertain significance Single submitter
- RAB29 p.Ser22Leu Uncertain significance Single submitter
- RAB29 p.Ser31Asn Uncertain significance Single submitter
- RAB29 p.Thr152Pro Uncertain significance Single submitter
- RAB29 p.Tyr78Cys Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RAB29 variants
Benign 1
- p.Gln104Glu Single submitter
Likely benign 1
- p.Leu123= No assertion criteria RAB29-related disorder
Uncertain significance 29
- p.Ala17Thr Single submitter ⚠
- p.Ala45Ser Single submitter ⚠
- p.Ala65Ser Single submitter ⚠
- p.Ala81Val Single submitter ⚠
- p.Arg136Gly Single submitter ⚠
- p.Arg141Gln Single submitter ⚠
- p.Arg141Gly Single submitter ⚠
- p.Arg141Trp Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg75Gln Single submitter
- p.Asn114Ser Single submitter ⚠
- p.Asn176Ile Single submitter ⚠
- p.Asn92Ser Single submitter ⚠
- p.Asp180Val Single submitter ⚠
- p.Asp53Ala Single submitter ⚠
- p.Glu55Lys Single submitter
- p.Gly147Ser Single submitter ⚠
- p.Gly2Cys Single submitter ⚠
- p.His35Arg Single submitter ⚠
- p.Leu23Val Single submitter ⚠
- p.Met182Thr Single submitter ⚠
- p.Met73Val Single submitter ⚠
- p.Ser22Leu Single submitter ⚠
- p.Ser31Asn Single submitter ⚠
- p.Thr152Pro Single submitter ⚠
- p.Trp132Leu Single submitter
- p.Tyr36Phe Single submitter ⚠
- p.Tyr78Cys Single submitter ⚠