RAB35 — 9 ClinVar variants
All ClinVar germline RAB35 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 4 flagged for review →
3 Likely benign · 6 Uncertain significance
Full RAB35 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 4
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All RAB35 variants
Uncertain significance 6
- p.Ala135Gly Single submitter
- p.Arg115Gln Single submitter
- p.Asn175Ser Single submitter ⚠
- p.Asp174Gly Single submitter ⚠
- p.Gly20Asp Single submitter ⚠
- p.Gly54Arg Single submitter ⚠