RAB44 — 5 ClinVar variants
All ClinVar germline RAB44 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1 flagged for review →
2 Likely benign · 3 Uncertain significance
Full RAB44 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 1
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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RAB44 p.Glu967Gln
Uncertain significance
Single submitter
familial meningioma
All RAB44 variants
Likely benign 2
- p.Glu695= Single submitter
- p.Ser778Pro Single submitter
Uncertain significance 3
- p.Asp216Val Single submitter familial meningioma
- p.Glu967Gln Single submitter familial meningioma ⚠
- p.Pro393fs Single submitter familial meningioma