RAB9A — 18 ClinVar variants
All ClinVar germline RAB9A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
1 Benign · 1 Likely benign · 16 Uncertain significance
Full RAB9A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAB9A p.Asn189Lys Uncertain significance Single submitter
- RAB9A p.Asp147Asn Uncertain significance Single submitter
- RAB9A p.Asp91Asn Uncertain significance Single submitter
- RAB9A p.Ile106Leu Uncertain significance Single submitter
- RAB9A p.Ile121Thr Uncertain significance Single submitter
- RAB9A p.Pro196Ala Uncertain significance Single submitter
- RAB9A p.Ser134Thr Uncertain significance Single submitter
- RAB9A p.Ser199Pro Uncertain significance Single submitter
- RAB9A p.Ser71Asn Uncertain significance Single submitter
- RAB9A p.Thr159Arg Uncertain significance Single submitter
- RAB9A p.Thr175Ile Uncertain significance Single submitter
- RAB9A p.Thr187Lys Uncertain significance Single submitter
- RAB9A p.Thr29Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RAB9A variants
Benign 1
- p.Ser198= Multiple submitters
Likely benign 1
- p.Asn145= Multiple submitters
Uncertain significance 16
- c.-116+3566G>A Single submitter
- p.Asn189Lys Single submitter ⚠
- p.Asn46Ser Single submitter ⚠
- p.Asp147Asn Single submitter ⚠
- p.Asp91Asn Single submitter ⚠
- p.Ile106Leu Single submitter ⚠
- p.Ile121Thr Single submitter ⚠
- p.Pro114Leu Single submitter ⚠
- p.Pro196Ala Single submitter ⚠
- p.Ser134Thr Single submitter ⚠
- p.Ser199Pro Single submitter ⚠
- p.Ser71Asn Single submitter ⚠
- p.Thr159Arg Single submitter ⚠
- p.Thr175Ile Single submitter ⚠
- p.Thr187Lys Single submitter ⚠
- p.Thr29Ile Single submitter ⚠