RAD1 — 50 ClinVar variants
All ClinVar germline RAD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
4 Benign · 6 Likely benign · 40 Uncertain significance
Full RAD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAD1 p.Ala196Thr Uncertain significance Single submitter
- RAD1 p.Ala40Thr Uncertain significance Single submitter
- RAD1 p.Ala63Thr Uncertain significance Single submitter
-
RAD1 p.Arg109Gln
Uncertain significance
Single submitter
RAD1-related disorder
- RAD1 p.Arg164His Uncertain significance Single submitter
- RAD1 p.Arg244Trp Uncertain significance Single submitter
- RAD1 p.Asn135His Uncertain significance Single submitter
- RAD1 p.Asp184Val Uncertain significance Single submitter
- RAD1 p.Asp91Glu Uncertain significance Single submitter
- RAD1 p.Cys215Tyr Uncertain significance Single submitter
- RAD1 p.Cys239Ser Uncertain significance Single submitter
- RAD1 p.Glu11Lys Uncertain significance Single submitter
- RAD1 p.Glu124Gly Uncertain significance Single submitter
- RAD1 p.Glu141Gly Uncertain significance Single submitter
- RAD1 p.Gly68Glu Uncertain significance Single submitter
-
RAD1 p.Ile156Thr
Uncertain significance
Single submitter
RAD1-related disorder
- RAD1 p.Ile264Val Uncertain significance Single submitter
- RAD1 p.Leu17Phe Uncertain significance Single submitter
- RAD1 p.Leu27Arg Uncertain significance Single submitter
- RAD1 p.Leu3Phe Uncertain significance Single submitter
- RAD1 p.Lys46Glu Uncertain significance Single submitter
- RAD1 p.Lys50Arg Uncertain significance Single submitter
- RAD1 p.Pro102Ser Uncertain significance Single submitter
- RAD1 p.Pro118Arg Uncertain significance Single submitter
- RAD1 p.Ser16Cys Uncertain significance Single submitter
- RAD1 p.Thr173Arg Uncertain significance Single submitter
- RAD1 p.Thr87Asn Uncertain significance Single submitter
- RAD1 p.Tyr203Asp Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- RAD1 p.Arg109Pro Uncertain significance Single submitter
- RAD1 p.Arg164Cys Uncertain significance Single submitter
- RAD1 p.Asp144Glu Uncertain significance Single submitter
- RAD1 p.Glu125Gly Uncertain significance Single submitter
- RAD1 p.Ile69Thr Uncertain significance Single submitter
- RAD1 p.Leu86Val Uncertain significance Single submitter
- RAD1 p.Phe82Leu Uncertain significance Single submitter
- RAD1 p.Ser174Asn Uncertain significance Single submitter
- RAD1 p.Ser226Phe Uncertain significance Single submitter
- RAD1 p.Val267Leu Uncertain significance Single submitter
All RAD1 variants
Benign 4
- c.666-9C>G No assertion criteria RAD1-related disorder
- p.Glu281Gly No assertion criteria RAD1-related disorder
- p.Gly114Asp No assertion criteria RAD1-related disorder
- p.Thr104Ser No assertion criteria RAD1-related disorder
Likely benign 6
- p.Asp261= Single submitter
- c.199-4A>G No assertion criteria RAD1-related disorder
- c.666-10del No assertion criteria RAD1-related disorder
- p.Leu93= No assertion criteria RAD1-related disorder
- p.Thr173= No assertion criteria RAD1-related disorder
- p.Tyr203Cys No assertion criteria RAD1-related disorder
Uncertain significance 40
- p.Ala196Thr Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Arg109Gln Single submitter RAD1-related disorder ⚠
- p.Arg109Pro Single submitter ⚠
- p.Arg109Ter Single submitter RAD1-related disorder
- p.Arg164Cys Single submitter ⚠
- p.Arg164His Single submitter ⚠
- p.Arg244Trp Single submitter ⚠
- p.Asn135His Single submitter ⚠
- p.Asp144Glu Single submitter ⚠
- p.Asp184Val Single submitter ⚠
- p.Asp91Glu Single submitter ⚠
- p.Cys215Tyr Single submitter ⚠
- p.Cys239Ser Single submitter ⚠
- p.Glu11Lys Single submitter ⚠
- p.Glu124Gly Single submitter ⚠
- p.Glu125Gly Single submitter ⚠
- p.Glu141Gly Single submitter ⚠
- p.Gly68Glu Single submitter ⚠
- p.Ile156Thr Single submitter RAD1-related disorder ⚠
- p.Ile264Val Single submitter ⚠
- p.Ile69Thr Single submitter ⚠
- p.Leu163Val Single submitter
- p.Leu17Phe Single submitter ⚠
- p.Leu27Arg Single submitter ⚠
- p.Leu3Phe Single submitter ⚠
- p.Leu86Val Single submitter ⚠
- p.Lys46Glu Single submitter ⚠
- p.Lys50Arg Single submitter ⚠
- p.Phe82Leu Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro118Arg Single submitter ⚠
- p.Ser16Cys Single submitter ⚠
- p.Ser174Asn Single submitter ⚠
- p.Ser226Phe Single submitter ⚠
- p.Thr173Arg Single submitter ⚠
- p.Thr87Asn Single submitter ⚠
- p.Tyr203Asp Single submitter ⚠
- p.Val267Leu Single submitter ⚠