RAD18 — 85 ClinVar variants

All ClinVar germline RAD18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →

2 Conflicting · 1 Likely benign · 82 Uncertain significance

Full RAD18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 81

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 68

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All RAD18 variants

Conflicting classifications of pathogenicity 2

p.Pro191Leu Single submitter ⚠
p.Pro242Leu Single submitter ⚠

Likely benign 1

p.Pro70= Single submitter

Uncertain significance 82

p.Ala101Gly Single submitter ⚠
p.Ala163Val Single submitter ⚠
p.Ala365Ser Single submitter ⚠
p.Ala481Thr Single submitter ⚠
p.Arg123Ser Single submitter ⚠
p.Arg131Ser Single submitter ⚠
p.Arg131Thr Single submitter ⚠
p.Arg173His Single submitter ⚠
p.Arg226Cys Single submitter ⚠
p.Arg254His Single submitter ⚠
p.Arg254Ser Single submitter ⚠
p.Arg302Gly Single submitter ⚠
p.Arg313His Single submitter ⚠
p.Arg358Gly Single submitter ⚠
p.Arg476Cys Single submitter ⚠
p.Arg51Gly Single submitter ⚠
p.Arg51Lys Single submitter ⚠
p.Arg76Cys Single submitter ⚠
p.Arg76His Single submitter ⚠
p.Asn135Lys Single submitter ⚠
p.Asn320His Single submitter ⚠
p.Asn320Ser Single submitter ⚠
p.Asn320Thr Single submitter ⚠
p.Asn33Ser Single submitter ⚠
p.Asn394Thr Single submitter ⚠
p.Asn400His Single submitter ⚠
p.Asn475Ser Single submitter ⚠
p.Asn495Thr Single submitter ⚠
p.Asn86Ser Single submitter ⚠
p.Asp355Tyr Single submitter ⚠
p.Asp378Val Single submitter ⚠
p.Asp426Tyr Single submitter ⚠
p.Asp464Asn Single submitter ⚠
p.Asp467Glu Single submitter ⚠
p.Cys49Ser Single submitter ⚠
p.Gln40Lys Single submitter ⚠
p.Gln94Leu Single submitter ⚠
p.Glu177Asp Single submitter ⚠
p.Glu305Lys Single submitter ⚠
p.Gly208Arg Single submitter ⚠
p.His278Leu Single submitter
p.His346Arg Single submitter ⚠
p.His461Leu Single submitter ⚠
p.Ile27Val Single submitter ⚠
p.Ile427Thr Single submitter ⚠
p.Leu22Trp Single submitter
p.Leu256Phe Single submitter ⚠
p.Leu314Val Single submitter ⚠
p.Leu48Val Single submitter ⚠
p.Lys110Asn Single submitter ⚠
p.Lys154Thr Single submitter ⚠
p.Lys161Glu Single submitter ⚠
p.Lys186Thr Single submitter ⚠
p.Lys201Glu Single submitter ⚠
p.Met133Arg Single submitter ⚠
p.Met133Ile Single submitter ⚠
p.Met284Val Single submitter ⚠
p.Met324Val Single submitter ⚠
p.Met367Ile Single submitter ⚠
p.Met367Lys Single submitter ⚠
p.Met36Val Single submitter ⚠
p.Phe326Ser Single submitter ⚠
p.Pro104Ala Single submitter ⚠
p.Pro159Leu Single submitter ⚠
p.Pro39Thr Single submitter
p.Pro410Leu Single submitter ⚠
p.Ser109Pro Single submitter ⚠
p.Ser144Phe Single submitter ⚠
p.Ser380Cys Single submitter ⚠
p.Ser403Tyr Single submitter ⚠
p.Ser422Cys Single submitter ⚠
p.Ser438Leu Single submitter ⚠
p.Ser442Cys Single submitter ⚠
p.Ser47Pro Single submitter ⚠
p.Ser483Asn Single submitter ⚠
p.Thr118Ala Single submitter ⚠
p.Thr145Ile Single submitter ⚠
p.Thr193Ala Single submitter ⚠
p.Thr193Ile Single submitter ⚠
p.Thr62Ala Single submitter ⚠
p.Val116Gly Single submitter ⚠
p.Val206Ile Single submitter ⚠