RAD23B — 37 ClinVar variants
All ClinVar germline RAD23B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
5 Likely benign · 32 Uncertain significance
Full RAD23B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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RAD23B p.Lys151Glu
Uncertain significance
Multiple submitters
RAD23B-related disorder
- RAD23B p.Ala209Ser Uncertain significance Single submitter
- RAD23B p.Ala245Val Uncertain significance Single submitter
- RAD23B p.Ala259Thr Uncertain significance Single submitter
- RAD23B p.Ala38Gly Uncertain significance Single submitter
- RAD23B p.Arg308Gln Uncertain significance Single submitter
- RAD23B p.Asp170Gly Uncertain significance Single submitter
- RAD23B p.Asp219His Uncertain significance Single submitter
- RAD23B p.Gln236Lys Uncertain significance Single submitter
- RAD23B p.Glu234Asp Uncertain significance Single submitter
- RAD23B p.Gly337Asp Uncertain significance Single submitter
- RAD23B p.Ile291Val Uncertain significance Single submitter
- RAD23B p.Lys144Glu Uncertain significance Single submitter
- RAD23B p.Pro128Ser Uncertain significance Single submitter
- RAD23B p.Pro161Ser Uncertain significance Single submitter
- RAD23B p.Pro250Ser Uncertain significance Single submitter
- RAD23B p.Ser102Ala Uncertain significance Single submitter
- RAD23B p.Ser168Leu Uncertain significance Single submitter
- RAD23B p.Ser91Leu Uncertain significance Single submitter
- RAD23B p.Thr155Ile Uncertain significance Single submitter
- RAD23B p.Thr162Lys Uncertain significance Single submitter
- RAD23B p.Thr22Ala Uncertain significance Single submitter
- RAD23B p.Thr261Ala Uncertain significance Single submitter
- RAD23B p.Thr265Ala Uncertain significance Single submitter
- RAD23B p.Thr268Ala Uncertain significance Single submitter
- RAD23B p.Val80Gly Uncertain significance Single submitter
-
RAD23B p.Ala124Val
Uncertain significance
No assertion criteria
RAD23B-related disorder
Predictors split 5
The independent predictors disagree with each other — read with care.
All RAD23B variants
Likely benign 5
- p.Ala143Thr Single submitter
- p.Leu373= Single submitter
- p.Thr268= Single submitter
- p.Asn217= No assertion criteria RAD23B-related disorder
- p.Lys151= No assertion criteria RAD23B-related disorder
Uncertain significance 32
- p.Lys151Glu Multiple submitters RAD23B-related disorder ⚠
- p.Ala209Ser Single submitter ⚠
- p.Ala245Val Single submitter ⚠
- p.Ala259Thr Single submitter ⚠
- p.Ala38Gly Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Asp170Gly Single submitter ⚠
- p.Asp219His Single submitter ⚠
- p.Gln236Lys Single submitter ⚠
- p.Glu146Gly Single submitter ⚠
- p.Glu234Asp Single submitter ⚠
- p.Gly337Asp Single submitter ⚠
- p.Ile229Leu Single submitter ⚠
- p.Ile291Val Single submitter ⚠
- p.Lys144Glu Single submitter ⚠
- p.Pro128Ser Single submitter ⚠
- p.Pro161Ser Single submitter ⚠
- p.Pro250Ser Single submitter ⚠
- p.Ser102Ala Single submitter ⚠
- p.Ser168Leu Single submitter ⚠
- p.Ser252Cys Single submitter ⚠
- p.Ser91Leu Single submitter ⚠
- p.Thr103Ile Single submitter ⚠
- p.Thr155Ile Single submitter ⚠
- p.Thr162Lys Single submitter ⚠
- p.Thr22Ala Single submitter ⚠
- p.Thr261Ala Single submitter ⚠
- p.Thr265Ala Single submitter ⚠
- p.Thr265Arg Single submitter ⚠
- p.Thr268Ala Single submitter ⚠
- p.Val80Gly Single submitter ⚠
- p.Ala124Val No assertion criteria RAD23B-related disorder ⚠