Sugi Variant

Sugi Variant/RAD51B

RAD51B — 647 ClinVar variants

All ClinVar germline RAD51B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 305 flagged for review →

1 Likely pathogenic · 9 Conflicting · 59 Benign · 5 Benign/Likely benign · 192 Likely benign · 381 Uncertain significance

Full RAD51B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 305

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 4

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 242

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 242

Predictors split 59

The independent predictors disagree with each other — read with care.

All RAD51B variants

Likely pathogenic 1

  • p.Gln258Ter Single submitter RAD51B-related cancer predisposition

Conflicting classifications of pathogenicity 9

Benign 59

Benign/Likely benign 5

  • c.316-6_316-3del Multiple submitters
  • p.Leu374Pro Multiple submitters hereditary breast ovarian cancer syndrome
  • p.Lys243Arg Multiple submitters hereditary breast ovarian cancer syndrome ⚠
  • p.Pro365Arg Multiple submitters hereditary breast ovarian cancer syndrome
  • p.Ser250Ala Multiple submitters hereditary breast ovarian cancer syndrome

Likely benign 192

Uncertain significance 381

Showing the top 300 by review status; the full set is in the sitemap.