RAD52 — 31 ClinVar variants
All ClinVar germline RAD52 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Benign · 3 Likely benign · 27 Uncertain significance
Full RAD52 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAD52 p.Arg180Cys Uncertain significance Single submitter
- RAD52 p.Asn99Ser Uncertain significance Single submitter
- RAD52 p.Gln30Pro Uncertain significance Single submitter
- RAD52 p.Glu145Lys Uncertain significance Single submitter
- RAD52 p.Glu288Asp Uncertain significance Single submitter
- RAD52 p.Gly150Glu Uncertain significance Single submitter
- RAD52 p.His121Arg Uncertain significance Single submitter
- RAD52 p.His216Asp Uncertain significance Single submitter
- RAD52 p.Leu182Phe Uncertain significance Single submitter
- RAD52 p.Leu184Val Uncertain significance Single submitter
- RAD52 p.Lys169Arg Uncertain significance Single submitter
- RAD52 p.Pro225Leu Uncertain significance Single submitter
- RAD52 p.Ser14Arg Uncertain significance Single submitter
- RAD52 p.Ser243Cys Uncertain significance Single submitter
- RAD52 p.Ser245Asn Uncertain significance Single submitter
- RAD52 p.Ser287Ile Uncertain significance Single submitter
- RAD52 p.Ser418Pro Uncertain significance Single submitter
- RAD52 p.Thr223Ala Uncertain significance Single submitter
- RAD52 p.Thr89Met Uncertain significance Single submitter
- RAD52 p.Val232Met Uncertain significance Single submitter
- RAD52 p.Val249Met Uncertain significance Single submitter
- RAD52 p.Val71Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RAD52 variants
Benign 1
- p.Gln221Glu Multiple submitters
Likely benign 3
- p.Tyr415Ter Multiple submitters
- p.Asp149= Single submitter
- p.Thr281Ala Single submitter
Uncertain significance 27
- c.84+1G>A Single submitter pilocytic astrocytoma
- p.Arg180Cys Single submitter ⚠
- p.Arg204Thr Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Asn99Ser Single submitter ⚠
- p.Gln30Pro Single submitter ⚠
- p.Glu145Lys Single submitter ⚠
- p.Glu288Asp Single submitter ⚠
- p.Gly150Glu Single submitter ⚠
- p.His121Arg Single submitter ⚠
- p.His216Asp Single submitter ⚠
- p.Ile166Thr Single submitter ⚠
- p.Leu182Phe Single submitter ⚠
- p.Leu184Val Single submitter ⚠
- p.Lys102Asn Single submitter ⚠
- p.Lys169Arg Single submitter ⚠
- p.Pro225Leu Single submitter ⚠
- p.Ser14Arg Single submitter ⚠
- p.Ser243Cys Single submitter ⚠
- p.Ser245Asn Single submitter ⚠
- p.Ser287Ile Single submitter ⚠
- p.Ser418Pro Single submitter ⚠
- p.Thr223Ala Single submitter ⚠
- p.Thr89Met Single submitter ⚠
- p.Val232Met Single submitter ⚠
- p.Val249Met Single submitter ⚠
- p.Val71Ile Single submitter ⚠