RAET1L — 54 ClinVar variants
All ClinVar germline RAET1L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Benign · 8 Likely benign · 44 Uncertain significance
Full RAET1L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAET1L p.Ala131Thr Uncertain significance Single submitter
- RAET1L p.Ala214Ser Uncertain significance Single submitter
- RAET1L p.Ala224Val Uncertain significance Single submitter
- RAET1L p.Ala51Val Uncertain significance Single submitter
- RAET1L p.Arg24Trp Uncertain significance Single submitter
- RAET1L p.Arg95Thr Uncertain significance Single submitter
- RAET1L p.Asn68Ser Uncertain significance Single submitter
- RAET1L p.Asp107Asn Uncertain significance Single submitter
- RAET1L p.Asp177Val Uncertain significance Single submitter
- RAET1L p.Asp28Glu Uncertain significance Single submitter
- RAET1L p.Asp29Glu Uncertain significance Single submitter
- RAET1L p.Glu154Lys Uncertain significance Single submitter
- RAET1L p.Gly145Arg Uncertain significance Single submitter
- RAET1L p.Gly192Glu Uncertain significance Single submitter
- RAET1L p.Gly21Cys Uncertain significance Single submitter
- RAET1L p.His134Tyr Uncertain significance Single submitter
- RAET1L p.Ile185Leu Uncertain significance Single submitter
- RAET1L p.Ile230Thr Uncertain significance Single submitter
- RAET1L p.Ile246Phe Uncertain significance Single submitter
- RAET1L p.Ile246Ser Uncertain significance Single submitter
- RAET1L p.Leu10Pro Uncertain significance Single submitter
- RAET1L p.Lys167Gln Uncertain significance Single submitter
- RAET1L p.Lys171Asn Uncertain significance Single submitter
- RAET1L p.Lys59Asn Uncertain significance Single submitter
- RAET1L p.Lys79Arg Uncertain significance Single submitter
- RAET1L p.Met180Lys Uncertain significance Single submitter
- RAET1L p.Pro207Thr Uncertain significance Single submitter
- RAET1L p.Pro212Leu Uncertain significance Single submitter
- RAET1L p.Pro73Thr Uncertain significance Single submitter
- RAET1L p.Ser216Tyr Uncertain significance Single submitter
- RAET1L p.Thr120Ile Uncertain significance Single submitter
- RAET1L p.Thr220Ile Uncertain significance Single submitter
- RAET1L p.Thr227Ser Uncertain significance Single submitter
- RAET1L p.Thr38Ser Uncertain significance Single submitter
- RAET1L p.Val56Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- RAET1L p.Ala123Glu Uncertain significance Single submitter
- RAET1L p.Gln53Pro Uncertain significance Single submitter
- RAET1L p.Gly54Asp Uncertain significance Single submitter
- RAET1L p.His162Pro Uncertain significance Single submitter
- RAET1L p.Leu121Pro Benign Single submitter
- RAET1L p.Leu121Val Uncertain significance Single submitter
- RAET1L p.Phe148Leu Uncertain significance Single submitter
- RAET1L p.Ser186Pro Uncertain significance Single submitter
- RAET1L p.Thr38Asn Uncertain significance Single submitter
- RAET1L p.Tyr113Cys Uncertain significance Single submitter
All RAET1L variants
Benign 2
- p.Ala123= Single submitter
- p.Leu121Pro Single submitter ⚠
Likely benign 8
- p.Arg48Trp Single submitter
- p.Asp28Ala Single submitter
- p.Glu103= Single submitter
- p.Gly192Arg Single submitter
- p.Ile191Thr Single submitter
- p.Ile6= Single submitter
- p.Leu213Pro Single submitter
- p.Val74Ile Single submitter
Uncertain significance 44
- p.Ala123Glu Single submitter ⚠
- p.Ala131Thr Single submitter ⚠
- p.Ala214Ser Single submitter ⚠
- p.Ala224Val Single submitter ⚠
- p.Ala51Val Single submitter ⚠
- p.Arg24Trp Single submitter ⚠
- p.Arg95Thr Single submitter ⚠
- p.Asn68Ser Single submitter ⚠
- p.Asp107Asn Single submitter ⚠
- p.Asp177Val Single submitter ⚠
- p.Asp28Glu Single submitter ⚠
- p.Asp29Glu Single submitter ⚠
- p.Gln53Pro Single submitter ⚠
- p.Glu154Lys Single submitter ⚠
- p.Gly145Arg Single submitter ⚠
- p.Gly192Glu Single submitter ⚠
- p.Gly21Cys Single submitter ⚠
- p.Gly54Asp Single submitter ⚠
- p.His134Tyr Single submitter ⚠
- p.His162Pro Single submitter ⚠
- p.Ile185Leu Single submitter ⚠
- p.Ile230Thr Single submitter ⚠
- p.Ile246Phe Single submitter ⚠
- p.Ile246Ser Single submitter ⚠
- p.Leu10Pro Single submitter ⚠
- p.Leu121Val Single submitter ⚠
- p.Lys167Gln Single submitter ⚠
- p.Lys171Asn Single submitter ⚠
- p.Lys59Asn Single submitter ⚠
- p.Lys79Arg Single submitter ⚠
- p.Met180Lys Single submitter ⚠
- p.Phe148Leu Single submitter ⚠
- p.Pro207Thr Single submitter ⚠
- p.Pro212Leu Single submitter ⚠
- p.Pro73Thr Single submitter ⚠
- p.Ser186Pro Single submitter ⚠
- p.Ser216Tyr Single submitter ⚠
- p.Thr120Ile Single submitter ⚠
- p.Thr220Ile Single submitter ⚠
- p.Thr227Ser Single submitter ⚠
- p.Thr38Asn Single submitter ⚠
- p.Thr38Ser Single submitter ⚠
- p.Tyr113Cys Single submitter ⚠
- p.Val56Met Single submitter ⚠