Sugi Variant

Sugi Variant/RAF1

RAF1 — 1320 ClinVar variants

All ClinVar germline RAF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 528 flagged for review →

13 Pathogenic · 15 Pathogenic/Likely pathogenic · 24 Likely pathogenic · 76 Conflicting · 72 Benign · 26 Benign/Likely benign · 463 Likely benign · 631 Uncertain significance

Full RAF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 528

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 3

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 27

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 344

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 344

Predictors split 154

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 154

All RAF1 variants

Pathogenic 13

Pathogenic/Likely pathogenic 15

Likely pathogenic 24

Conflicting classifications of pathogenicity 76

Benign 72

Benign/Likely benign 26

Likely benign 463

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 631

Showing the top 300 by review status; the full set is in the sitemap.