RAMP2 — 24 ClinVar variants
All ClinVar germline RAMP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
3 Likely benign · 21 Uncertain significance
Full RAMP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAMP2 p.Ala9Thr Uncertain significance Single submitter
- RAMP2 p.Arg13Gly Uncertain significance Single submitter
- RAMP2 p.Arg18Gly Uncertain significance Single submitter
- RAMP2 p.Gln125His Uncertain significance Single submitter
- RAMP2 p.Gln43Arg Uncertain significance Single submitter
- RAMP2 p.Glu122Gln Uncertain significance Single submitter
- RAMP2 p.Glu7Gln Uncertain significance Single submitter
- RAMP2 p.Gly11Cys Uncertain significance Single submitter
- RAMP2 p.Gly55Ala Uncertain significance Single submitter
- RAMP2 p.Leu14Phe Uncertain significance Single submitter
- RAMP2 p.Leu163Pro Uncertain significance Single submitter
- RAMP2 p.Leu41Pro Uncertain significance Single submitter
- RAMP2 p.Pro153Ser Uncertain significance Single submitter
- RAMP2 p.Ser139Phe Uncertain significance Single submitter
- RAMP2 p.Ser168Asn Uncertain significance Single submitter
- RAMP2 p.Thr137Ser Uncertain significance Single submitter
- RAMP2 p.Val34Ala Uncertain significance Single submitter
- RAMP2 p.Val6Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RAMP2 variants
Likely benign 3
- p.Arg97Gln Single submitter
- p.Asp140= Single submitter
- p.Thr57Met Single submitter
Uncertain significance 21
- p.Ala9Thr Single submitter ⚠
- p.Arg13Gly Single submitter ⚠
- p.Arg18Gly Single submitter ⚠
- p.Cys155Tyr Single submitter ⚠
- p.Gln125His Single submitter ⚠
- p.Gln43Arg Single submitter ⚠
- p.Glu122Gln Single submitter ⚠
- p.Glu7Gln Single submitter ⚠
- p.Gly11Cys Single submitter ⚠
- p.Gly55Ala Single submitter ⚠
- p.Leu14Phe Single submitter ⚠
- p.Leu156Phe Single submitter
- p.Leu163Pro Single submitter ⚠
- p.Leu41Pro Single submitter ⚠
- p.Met149Thr Single submitter ⚠
- p.Pro153Ser Single submitter ⚠
- p.Ser139Phe Single submitter ⚠
- p.Ser168Asn Single submitter ⚠
- p.Thr137Ser Single submitter ⚠
- p.Val34Ala Single submitter ⚠
- p.Val6Met Single submitter ⚠