RAMP3 — 16 ClinVar variants
All ClinVar germline RAMP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
2 Benign · 2 Likely benign · 12 Uncertain significance
Full RAMP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAMP3 p.Arg7Trp Uncertain significance Single submitter
- RAMP3 p.Asp107Tyr Uncertain significance Single submitter
- RAMP3 p.Cys22Arg Uncertain significance Single submitter
- RAMP3 p.Glu30Asp Uncertain significance Single submitter
- RAMP3 p.Gly135Val Uncertain significance Single submitter
- RAMP3 p.Gly49Asp Uncertain significance Single submitter
- RAMP3 p.His110Tyr Uncertain significance Single submitter
- RAMP3 p.Pro87Ser Uncertain significance Single submitter
- RAMP3 p.Pro9Leu Uncertain significance Single submitter
- RAMP3 p.Ser68Arg Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RAMP3 variants
Benign 2
- p.Gly26Asp Single submitter
- p.Met33Leu Single submitter
Likely benign 2
- p.Thr73= Single submitter
- p.Val124Ile Single submitter
Uncertain significance 12
- p.Arg7Trp Single submitter ⚠
- p.Asp107Tyr Single submitter ⚠
- p.Cys22Arg Single submitter ⚠
- p.Glu30Asp Single submitter ⚠
- p.Gly135Val Single submitter ⚠
- p.Gly49Asp Single submitter ⚠
- p.His110Tyr Single submitter ⚠
- p.Leu11Phe Single submitter ⚠
- p.Met33Thr Single submitter ⚠
- p.Pro87Ser Single submitter ⚠
- p.Pro9Leu Single submitter ⚠
- p.Ser68Arg Single submitter ⚠