RANBP1 — 19 ClinVar variants
All ClinVar germline RANBP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
1 Benign · 1 Likely benign · 17 Uncertain significance
Full RANBP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RANBP1 p.Ala258Val Uncertain significance Single submitter
- RANBP1 p.Arg168Gln Uncertain significance Single submitter
- RANBP1 p.Asp194Asn Uncertain significance Single submitter
- RANBP1 p.Asp207Asn Uncertain significance Single submitter
- RANBP1 p.Asp87Tyr Uncertain significance Single submitter
- RANBP1 p.Asp89His Uncertain significance Single submitter
- RANBP1 p.Glu186Asp Uncertain significance Single submitter
- RANBP1 p.Glu238Gln Uncertain significance Single submitter
- RANBP1 p.Glu255Lys Uncertain significance Single submitter
- RANBP1 p.Glu268Ala Uncertain significance Single submitter
- RANBP1 p.His85Gln Uncertain significance Single submitter
- RANBP1 p.Ile239Met Uncertain significance Single submitter
- RANBP1 p.Met184Thr Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RANBP1 variants
Benign 1
- p.Ala258= Multiple submitters
Likely benign 1
- p.Ser81= Single submitter
Uncertain significance 17
- p.Ala258Val Single submitter ⚠
- p.Arg168Gln Single submitter ⚠
- p.Asp194Asn Single submitter ⚠
- p.Asp207Asn Single submitter ⚠
- p.Asp87Tyr Single submitter ⚠
- p.Asp89His Single submitter ⚠
- p.Glu186Asp Single submitter ⚠
- p.Glu238Gln Single submitter ⚠
- p.Glu255Gly Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.Glu268Ala Single submitter ⚠
- p.His85Gln Single submitter ⚠
- p.Ile239Met Single submitter ⚠
- p.Met128Ile Single submitter ⚠
- p.Met184Thr Single submitter ⚠
- p.Ser265Leu Single submitter ⚠
- p.Val152Ile Single submitter ⚠