RANGRF — 159 ClinVar variants
All ClinVar germline RANGRF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
2 Conflicting · 4 Benign · 2 Benign/Likely benign · 61 Likely benign · 90 Uncertain significance
Full RANGRF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
RANGRF p.Leu18Phe
Conflicting
Single submitter
cardiac rhythm disease
-
RANGRF p.Val58Ile
Conflicting
Single submitter
cardiac rhythm disease
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
RANGRF p.Ala119Glu
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.Ala56Val
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.Arg130Lys
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.Asp179Asn
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.Glu114Asp
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.Glu83Asp
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.His81Arg
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.Pro162Ser
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.Ser84Ala
Uncertain significance
Multiple submitters
cardiac rhythm disease
-
RANGRF p.Val122Met
Uncertain significance
Multiple submitters
cardiac rhythm disease
- RANGRF p.Ala112Thr Uncertain significance Single submitter
-
RANGRF p.Ala56Asp
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Ala62Gly
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Arg59Gly
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Arg59Leu
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Arg59Pro
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Arg59Trp
Uncertain significance
Single submitter
cardiac rhythm disease
- RANGRF p.Arg5Lys Uncertain significance Single submitter
-
RANGRF p.Arg65Leu
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Asn143Lys
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Asn143Ser
Uncertain significance
Single submitter
cardiac rhythm disease
- RANGRF p.Asn157Tyr Uncertain significance Single submitter
-
RANGRF p.Asp148His
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Cys7Phe
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Gln116His
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Gln133Arg
Uncertain significance
Single submitter
cardiac rhythm disease
- RANGRF p.Gln186Pro Uncertain significance Single submitter
- RANGRF p.Gln75Arg Uncertain significance Single submitter
-
RANGRF p.Gln86Glu
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Glu2Gly
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Glu50Lys
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Glu83Gly
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Glu83Lys
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Gly12Asp
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Gly60Asp
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.His178Gln
Uncertain significance
Single submitter
cardiac rhythm disease
- RANGRF p.His67Gln Uncertain significance Single submitter
-
RANGRF p.Ile17Asn
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Ile23Phe
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Ile23Val
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Leu140Val
Uncertain significance
Single submitter
cardiac rhythm disease
- RANGRF p.Leu165Met Uncertain significance Single submitter
-
RANGRF p.Leu165Pro
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Leu175Val
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Leu18Ile
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Met20Leu
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Met20Thr
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Phe14Ser
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Phe68Ile
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Pro146Leu
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Pro147Arg
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Pro87Ser
Uncertain significance
Single submitter
cardiac rhythm disease
- RANGRF p.Pro8Ser Uncertain significance Single submitter
-
RANGRF p.Ser159Leu
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Thr4Arg
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Val31Gly
Uncertain significance
Single submitter
cardiac rhythm disease
- RANGRF p.Val74Leu Uncertain significance Single submitter
-
RANGRF p.Val80Ile
Uncertain significance
Single submitter
cardiac rhythm disease
- RANGRF p.Val85Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
-
RANGRF p.Ala64Thr
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Asp179Tyr
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Ile48Thr
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Pro145Leu
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Pro145Thr
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Tyr66Cys
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Val37Ile
Uncertain significance
Single submitter
cardiac rhythm disease
-
RANGRF p.Val58Glu
Uncertain significance
Single submitter
cardiac rhythm disease
All RANGRF variants
Conflicting classifications of pathogenicity 2
- p.Leu18Phe Single submitter cardiac rhythm disease ⚠
- p.Val58Ile Single submitter cardiac rhythm disease ⚠
Benign 4
- c.437+16C>T Multiple submitters cardiac rhythm disease
- c.77+19C>G Multiple submitters cardiac rhythm disease
- p.Asp27= Multiple submitters cardiac rhythm disease
- p.Gln170= Multiple submitters cardiac rhythm disease
Benign/Likely benign 2
- c.194+17C>G Multiple submitters cardiac rhythm disease
- p.Glu61Ter Multiple submitters cardiac rhythm disease
Likely benign 61
- c.194+13C>T Multiple submitters cardiac rhythm disease
- c.351+10C>T Multiple submitters cardiac rhythm disease
- c.437+20C>T Multiple submitters cardiac rhythm disease
- p.Leu9= Multiple submitters cardiac rhythm disease
- p.Val104= Multiple submitters cardiac rhythm disease
- c.194+10T>C Single submitter cardiac rhythm disease
- c.194+14C>T Single submitter cardiac rhythm disease
- c.194+15C>A Single submitter cardiac rhythm disease
- c.194+15C>T Single submitter cardiac rhythm disease
- c.194+17C>T Single submitter cardiac rhythm disease
- c.194+18G>A Single submitter cardiac rhythm disease
- c.194+8A>G Single submitter cardiac rhythm disease
- c.194+9A>C Single submitter cardiac rhythm disease
- c.195-15G>A Single submitter cardiac rhythm disease
- c.195-4C>T Single submitter cardiac rhythm disease
- c.195-8T>C Single submitter cardiac rhythm disease
- c.351+10C>G Single submitter cardiac rhythm disease
- c.351+12A>G Single submitter cardiac rhythm disease
- c.351+13G>T Single submitter cardiac rhythm disease
- c.351+7G>A Single submitter cardiac rhythm disease
- c.437+17G>A Single submitter cardiac rhythm disease
- c.437+9G>A Single submitter cardiac rhythm disease
- c.438-12C>T Single submitter cardiac rhythm disease
- c.438-13C>A Single submitter cardiac rhythm disease
- c.438-16G>C Single submitter cardiac rhythm disease
- c.438-8A>G Single submitter cardiac rhythm disease
- c.77+11C>A Single submitter
- c.77+14G>A Single submitter cardiac rhythm disease
- c.77+18C>T Single submitter cardiac rhythm disease
- c.77+8G>A Single submitter cardiac rhythm disease
- c.-19A>C Single submitter
- c.-2C>T Single submitter
- c.-45A>C Single submitter
- p.Ala62= Single submitter cardiac rhythm disease
- p.Ala63= Single submitter cardiac rhythm disease
- p.Arg130= Single submitter cardiac rhythm disease
- p.Arg59= Single submitter cardiac rhythm disease
- p.Asn143= Single submitter cardiac rhythm disease
- p.Asn149= Single submitter cardiac rhythm disease
- p.Asn181= Single submitter cardiac rhythm disease
- p.Cys7= Single submitter cardiac rhythm disease
- p.Glu69= Single submitter cardiac rhythm disease
- p.Glu83= Single submitter
- p.Gly184= Single submitter cardiac rhythm disease
- p.Gly60= Single submitter cardiac rhythm disease
- p.Gly73= Single submitter cardiac rhythm disease
- p.His178= Single submitter cardiac rhythm disease
- p.His57= Single submitter cardiac rhythm disease
- p.Leu129= Single submitter cardiac rhythm disease
- p.Leu165= Single submitter cardiac rhythm disease
- p.Leu171= Single submitter cardiac rhythm disease
- p.Pro132= Single submitter cardiac rhythm disease
- p.Pro155= Single submitter cardiac rhythm disease
- p.Pro185= Single submitter cardiac rhythm disease
- p.Pro19= Single submitter cardiac rhythm disease
- p.Thr136= Single submitter cardiac rhythm disease
- p.Thr176= Single submitter
- p.Thr4= Single submitter cardiac rhythm disease
- p.Tyr134= Single submitter
- p.Val25= Single submitter cardiac rhythm disease
- p.Val42Leu Single submitter cardiac rhythm disease
Uncertain significance 90
- c.77+5G>A Multiple submitters cardiac rhythm disease
- p.Ala119Glu Multiple submitters cardiac rhythm disease ⚠
- p.Ala56Val Multiple submitters cardiac rhythm disease ⚠
- p.Arg130Lys Multiple submitters cardiac rhythm disease ⚠
- p.Asp179Asn Multiple submitters cardiac rhythm disease ⚠
- p.Asp6fs Multiple submitters cardiac rhythm disease
- p.Glu114Asp Multiple submitters cardiac rhythm disease ⚠
- p.Glu83Asp Multiple submitters cardiac rhythm disease ⚠
- p.His81Arg Multiple submitters cardiac rhythm disease ⚠
- p.Pro162Ser Multiple submitters cardiac rhythm disease ⚠
- p.Ser84Ala Multiple submitters cardiac rhythm disease ⚠
- p.Val122Met Multiple submitters cardiac rhythm disease ⚠
- p.Val58Leu Multiple submitters cardiac rhythm disease
- c.194+1G>A Single submitter
- c.194+6G>A Single submitter cardiac rhythm disease
- c.194+6G>T Single submitter cardiac rhythm disease
- c.351+3G>T Single submitter cardiac rhythm disease
- c.351+4_351+19del Single submitter cardiac rhythm disease
- c.351+6G>A Single submitter cardiac rhythm disease
- c.437+3A>G Single submitter cardiac rhythm disease
- c.437+9G>T Single submitter cardiac rhythm disease
- p.Ala112Thr Single submitter ⚠
- p.Ala22fs Single submitter cardiac rhythm disease
- p.Ala56Asp Single submitter cardiac rhythm disease ⚠
- p.Ala62Gly Single submitter cardiac rhythm disease ⚠
- p.Ala64Thr Single submitter cardiac rhythm disease ⚠
- p.Arg59Gly Single submitter cardiac rhythm disease ⚠
- p.Arg59Leu Single submitter cardiac rhythm disease ⚠
- p.Arg59Pro Single submitter cardiac rhythm disease ⚠
- p.Arg59Trp Single submitter cardiac rhythm disease ⚠
- p.Arg5Lys Single submitter ⚠
- p.Arg65Leu Single submitter cardiac rhythm disease ⚠
- p.Asn143Lys Single submitter cardiac rhythm disease ⚠
- p.Asn143Ser Single submitter cardiac rhythm disease ⚠
- p.Asn157Tyr Single submitter ⚠
- p.Asp148His Single submitter cardiac rhythm disease ⚠
- p.Asp179Tyr Single submitter cardiac rhythm disease ⚠
- p.Asp70Asn Single submitter cardiac rhythm disease
- p.Cys7Phe Single submitter cardiac rhythm disease ⚠
- p.Gln116His Single submitter cardiac rhythm disease ⚠
- p.Gln133Arg Single submitter cardiac rhythm disease ⚠
- p.Gln133Ter Single submitter cardiac rhythm disease
- p.Gln186Pro Single submitter ⚠
- p.Gln55Ter Single submitter cardiac rhythm disease
- p.Gln75Arg Single submitter ⚠
- p.Gln86Glu Single submitter cardiac rhythm disease ⚠
- p.Gln86Ter Single submitter cardiac rhythm disease
- p.Glu2Gly Single submitter cardiac rhythm disease ⚠
- p.Glu50Lys Single submitter cardiac rhythm disease ⚠
- p.Glu83Gly Single submitter cardiac rhythm disease ⚠
- p.Glu83Lys Single submitter cardiac rhythm disease ⚠
- p.Gly12Asp Single submitter cardiac rhythm disease ⚠
- p.Gly184Val Single submitter cardiac rhythm disease
- p.Gly60Asp Single submitter cardiac rhythm disease ⚠
- p.His178Gln Single submitter cardiac rhythm disease ⚠
- p.His67Gln Single submitter ⚠
- p.Ile17Asn Single submitter cardiac rhythm disease ⚠
- p.Ile23Phe Single submitter cardiac rhythm disease ⚠
- p.Ile23Val Single submitter cardiac rhythm disease ⚠
- p.Ile48Thr Single submitter cardiac rhythm disease ⚠
- p.Leu124del Single submitter cardiac rhythm disease
- p.Leu140Val Single submitter cardiac rhythm disease ⚠
- p.Leu165Met Single submitter ⚠
- p.Leu165Pro Single submitter cardiac rhythm disease ⚠
- p.Leu175Val Single submitter cardiac rhythm disease ⚠
- p.Leu18Ile Single submitter cardiac rhythm disease ⚠
- p.Lys120Ter Single submitter cardiac rhythm disease
- p.Met1Lys Single submitter cardiac rhythm disease
- p.Met20Leu Single submitter cardiac rhythm disease ⚠
- p.Met20Thr Single submitter cardiac rhythm disease ⚠
- p.Phe14Ser Single submitter cardiac rhythm disease ⚠
- p.Phe68Ile Single submitter cardiac rhythm disease ⚠
- p.Pro145Leu Single submitter cardiac rhythm disease ⚠
- p.Pro145Thr Single submitter cardiac rhythm disease ⚠
- p.Pro146= Single submitter cardiac rhythm disease
- p.Pro146Leu Single submitter cardiac rhythm disease ⚠
- p.Pro147Arg Single submitter cardiac rhythm disease ⚠
- p.Pro147fs Single submitter cardiac rhythm disease
- p.Pro87Ser Single submitter cardiac rhythm disease ⚠
- p.Pro8Ser Single submitter ⚠
- p.Ser159Leu Single submitter cardiac rhythm disease ⚠
- p.Thr4Arg Single submitter cardiac rhythm disease ⚠
- p.Tyr66Cys Single submitter cardiac rhythm disease ⚠
- p.Tyr66Ter Single submitter cardiac rhythm disease
- p.Val31Gly Single submitter cardiac rhythm disease ⚠
- p.Val37Ile Single submitter cardiac rhythm disease ⚠
- p.Val58Glu Single submitter cardiac rhythm disease ⚠
- p.Val74Leu Single submitter ⚠
- p.Val80Ile Single submitter cardiac rhythm disease ⚠
- p.Val85Ile Single submitter ⚠