RAP2C — 8 ClinVar variants
All ClinVar germline RAP2C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
1 Benign · 1 Likely benign · 6 Uncertain significance
Full RAP2C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All RAP2C variants
Benign 1
- p.Thr178= Single submitter
Likely benign 1
- p.Tyr106= Single submitter
Uncertain significance 6
- p.Arg2Lys Single submitter ⚠
- p.Asp174Tyr Single submitter ⚠
- p.Leu156Val Single submitter ⚠
- p.Lys73Arg Single submitter ⚠
- p.Phe28Leu Single submitter ⚠
- p.Val81Ile Single submitter ⚠