RARA — 52 ClinVar variants
All ClinVar germline RARA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Conflicting · 4 Benign · 4 Likely benign · 43 Uncertain significance
Full RARA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
RARA p.Arg276Gln
Conflicting
Single submitter
Inborn genetic diseases
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RARA p.Ala438Val Uncertain significance Single submitter
- RARA p.Arg162Gln Uncertain significance Single submitter
-
RARA p.Arg276Trp
Uncertain significance
Single submitter
syndromic disease
- RARA p.Arg347Leu Uncertain significance Single submitter
- RARA p.Arg394Gln Uncertain significance Single submitter
- RARA p.Arg432Gln Uncertain significance Single submitter
- RARA p.Asn17Ser Uncertain significance Single submitter
- RARA p.Asp226Val Uncertain significance Single submitter
- RARA p.Asp323Glu Uncertain significance Single submitter
- RARA p.Gly12Ala Uncertain significance Single submitter
- RARA p.Gly425Arg Uncertain significance Single submitter
- RARA p.Gly428Glu Uncertain significance Single submitter
- RARA p.Gly428Val Uncertain significance Single submitter
- RARA p.Gly430Arg Uncertain significance Single submitter
- RARA p.Gly436Asp Uncertain significance Single submitter
- RARA p.Gly436Ser Uncertain significance Single submitter
-
RARA p.Gly52Glu
Uncertain significance
Single submitter
familial meningioma
- RARA p.Ile131Val Uncertain significance Single submitter
- RARA p.Ile381Val Uncertain significance Single submitter
- RARA p.Lys155Arg Uncertain significance Single submitter
- RARA p.Met413Ile Uncertain significance Single submitter
- RARA p.Phe111Cys Uncertain significance Single submitter
- RARA p.Pro182Leu Uncertain significance Single submitter
- RARA p.Pro20Ala Uncertain significance Single submitter
- RARA p.Pro37Leu Uncertain significance Single submitter
- RARA p.Pro427Leu Uncertain significance Single submitter
- RARA p.Pro440Leu Uncertain significance Single submitter
- RARA p.Pro446Arg Uncertain significance Single submitter
- RARA p.Pro450His Uncertain significance Single submitter
-
RARA p.Pro9Leu
Uncertain significance
Single submitter
familial meningioma
- RARA p.Ser175Phe Uncertain significance Single submitter
-
RARA p.Ser7Cys
Uncertain significance
Single submitter
familial meningioma
- RARA p.Thr179Met Uncertain significance Single submitter
- RARA p.Thr275Met Uncertain significance Single submitter
- RARA p.Thr397Met Uncertain significance Single submitter
- RARA p.Thr459Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- RARA p.Ala104Thr Uncertain significance Single submitter
- RARA p.Arg370Cys Uncertain significance Single submitter
- RARA p.Cys235Ser Uncertain significance Single submitter
-
RARA p.Glu357Asp
Uncertain significance
Single submitter
colorectal carcinoma
- RARA p.Met120Val Uncertain significance Single submitter
- RARA p.Met321Ile Uncertain significance Single submitter
All RARA variants
Conflicting classifications of pathogenicity 1
- p.Arg276Gln Single submitter Inborn genetic diseases ⚠
Benign 4
- p.Pro279= Multiple submitters
- c.1013-6C>T Single submitter
- c.179-3622C>T Single submitter
- c.469+9C>T Single submitter
Likely benign 4
Uncertain significance 43
- p.Ala104Thr Single submitter ⚠
- p.Ala438Val Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg276Trp Single submitter syndromic disease ⚠
- p.Arg347Leu Single submitter ⚠
- p.Arg370Cys Single submitter ⚠
- p.Arg394Gln Single submitter ⚠
- p.Arg432Gln Single submitter ⚠
- p.Asn17Ser Single submitter ⚠
- p.Asp226Val Single submitter ⚠
- p.Asp323Glu Single submitter ⚠
- p.Cys235Ser Single submitter ⚠
- p.Glu357Asp Single submitter colorectal carcinoma ⚠
- p.Gly12Ala Single submitter ⚠
- p.Gly425Arg Single submitter ⚠
- p.Gly428Glu Single submitter ⚠
- p.Gly428Val Single submitter ⚠
- p.Gly430Arg Single submitter ⚠
- p.Gly436Asp Single submitter ⚠
- p.Gly436Ser Single submitter ⚠
- p.Gly52Glu Single submitter familial meningioma ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile381Val Single submitter ⚠
- p.Lys155Arg Single submitter ⚠
- p.Met120Val Single submitter ⚠
- p.Met321Ile Single submitter ⚠
- p.Met413Ile Single submitter ⚠
- p.Phe111Cys Single submitter ⚠
- p.Pro182Leu Single submitter ⚠
- p.Pro20Ala Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Pro427Leu Single submitter ⚠
- p.Pro440Leu Single submitter ⚠
- p.Pro446Arg Single submitter ⚠
- p.Pro450His Single submitter ⚠
- p.Pro9Leu Single submitter familial meningioma ⚠
- p.Ser175Phe Single submitter ⚠
- p.Ser7Cys Single submitter familial meningioma ⚠
- p.Thr179Met Single submitter ⚠
- p.Thr275Met Single submitter ⚠
- p.Thr397Met Single submitter ⚠
- p.Thr459Ile Single submitter ⚠
- p.Gly337= No assertion criteria Mendelian syndromes with cleft lip/palate