RARG — 30 ClinVar variants
All ClinVar germline RARG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Likely pathogenic · 1 Benign · 1 Likely benign · 27 Uncertain significance
Full RARG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RARG p.Ala10Glu Uncertain significance Single submitter
- RARG p.Ala10Val Uncertain significance Single submitter
- RARG p.Ala28Thr Uncertain significance Single submitter
- RARG p.Arg128Cys Uncertain significance Single submitter
- RARG p.Arg128His Uncertain significance Single submitter
- RARG p.Arg141His Uncertain significance Single submitter
- RARG p.Arg164Trp Uncertain significance Single submitter
- RARG p.Arg413Gln Uncertain significance Single submitter
- RARG p.Asn94Ser Uncertain significance Single submitter
- RARG p.Asp217Glu Uncertain significance Single submitter
- RARG p.Glu174Gln Uncertain significance Single submitter
- RARG p.Glu348Asp Uncertain significance Single submitter
- RARG p.Gly175Ala Uncertain significance Single submitter
- RARG p.Gly339Arg Uncertain significance Single submitter
- RARG p.Met402Thr Uncertain significance Single submitter
- RARG p.Ser437Ile Uncertain significance Single submitter
- RARG p.Tyr374His Uncertain significance Single submitter
- RARG p.Val171Leu Uncertain significance Single submitter
- RARG p.Val171Met Uncertain significance Single submitter
- RARG p.Val193Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RARG variants
Likely pathogenic 1
- p.Arg413Ter No assertion criteria epithelial squamous dysplasia, keratinizing desquamative, of urinary tract
Benign 1
- p.Ser427Leu Multiple submitters
Likely benign 1
- p.Pro82Leu Single submitter Peters anomaly
Uncertain significance 27
- c.813+2T>G Single submitter
- p.Ala10Glu Single submitter ⚠
- p.Ala10Val Single submitter ⚠
- p.Ala28Thr Single submitter ⚠
- p.Ala365Asp Single submitter ⚠
- p.Arg128Cys Single submitter ⚠
- p.Arg128His Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg164Trp Single submitter ⚠
- p.Arg413Gln Single submitter ⚠
- p.Asn165Lys Single submitter ⚠
- p.Asn94Ser Single submitter ⚠
- p.Asp217Glu Single submitter ⚠
- p.Glu174Gln Single submitter ⚠
- p.Glu348Asp Single submitter ⚠
- p.Gly175Ala Single submitter ⚠
- p.Gly24Arg Single submitter
- p.Gly316Glu Single submitter
- p.Gly339Arg Single submitter ⚠
- p.Met342Val Single submitter ⚠
- p.Met402Thr Single submitter ⚠
- p.Pro184Arg Single submitter ⚠
- p.Ser437Ile Single submitter ⚠
- p.Tyr374His Single submitter ⚠
- p.Val171Leu Single submitter ⚠
- p.Val171Met Single submitter ⚠
- p.Val193Ile Single submitter ⚠