RASGRP3 — 75 ClinVar variants
All ClinVar germline RASGRP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
1 Benign · 5 Likely benign · 69 Uncertain significance
Full RASGRP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RASGRP3 p.Ala548Thr Uncertain significance Single submitter
- RASGRP3 p.Ala550Val Uncertain significance Single submitter
- RASGRP3 p.Ala644Val Uncertain significance Single submitter
- RASGRP3 p.Ala651Ser Uncertain significance Single submitter
- RASGRP3 p.Arg255His Uncertain significance Single submitter
- RASGRP3 p.Arg545Lys Uncertain significance Single submitter
- RASGRP3 p.Arg549Gln Uncertain significance Single submitter
- RASGRP3 p.Arg584Gly Uncertain significance Single submitter
- RASGRP3 p.Arg599Cys Uncertain significance Single submitter
- RASGRP3 p.Arg599His Uncertain significance Single submitter
- RASGRP3 p.Arg669Gln Uncertain significance Single submitter
- RASGRP3 p.Arg669Trp Uncertain significance Single submitter
- RASGRP3 p.Asn227Ser Uncertain significance Single submitter
- RASGRP3 p.Asn272Ser Uncertain significance Single submitter
- RASGRP3 p.Asn286His Uncertain significance Single submitter
- RASGRP3 p.Asn286Ser Uncertain significance Single submitter
- RASGRP3 p.Asn418Lys Uncertain significance Single submitter
- RASGRP3 p.Asn496Ser Uncertain significance Single submitter
- RASGRP3 p.Asp293Asn Uncertain significance Single submitter
- RASGRP3 p.Asp371His Uncertain significance Single submitter
- RASGRP3 p.Asp647Glu Uncertain significance Single submitter
- RASGRP3 p.Asp668Val Uncertain significance Single submitter
- RASGRP3 p.Asp678Glu Uncertain significance Single submitter
- RASGRP3 p.Cys536Arg Uncertain significance Single submitter
- RASGRP3 p.Cys57Gly Uncertain significance Single submitter
- RASGRP3 p.Cys67Phe Uncertain significance Single submitter
- RASGRP3 p.Gly142Arg Uncertain significance Single submitter
- RASGRP3 p.His486Arg Uncertain significance Single submitter
- RASGRP3 p.His557Arg Uncertain significance Single submitter
- RASGRP3 p.His661Arg Uncertain significance Single submitter
- RASGRP3 p.Ile226Val Uncertain significance Single submitter
- RASGRP3 p.Ile301Thr Uncertain significance Single submitter
- RASGRP3 p.Ile518Leu Uncertain significance Single submitter
- RASGRP3 p.Leu117Phe Uncertain significance Single submitter
- RASGRP3 p.Leu360Pro Uncertain significance Single submitter
- RASGRP3 p.Leu6Phe Uncertain significance Single submitter
- RASGRP3 p.Lys140Arg Uncertain significance Single submitter
- RASGRP3 p.Lys289Arg Uncertain significance Single submitter
- RASGRP3 p.Lys411Thr Uncertain significance Single submitter
- RASGRP3 p.Met58Ile Uncertain significance Single submitter
- RASGRP3 p.Pro382Ala Uncertain significance Single submitter
- RASGRP3 p.Ser139Pro Uncertain significance Single submitter
- RASGRP3 p.Ser252Tyr Uncertain significance Single submitter
- RASGRP3 p.Ser598Pro Uncertain significance Single submitter
- RASGRP3 p.Thr214Ile Uncertain significance Single submitter
- RASGRP3 p.Thr415Lys Uncertain significance Single submitter
- RASGRP3 p.Thr506Ile Uncertain significance Single submitter
- RASGRP3 p.Val209Ile Uncertain significance Single submitter
- RASGRP3 p.Val244Met Uncertain significance Single submitter
- RASGRP3 p.Val594Ile Uncertain significance Single submitter
- RASGRP3 p.Val660Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- RASGRP3 p.Asn345Ile Uncertain significance Single submitter
- RASGRP3 p.Asn531Ser Uncertain significance Single submitter
- RASGRP3 p.His150Arg Uncertain significance Single submitter
- RASGRP3 p.His165Asp Uncertain significance Single submitter
- RASGRP3 p.Lys488Glu Uncertain significance Single submitter
- RASGRP3 p.Met129Ile Uncertain significance Single submitter
- RASGRP3 p.Phe297Leu Uncertain significance Single submitter
- RASGRP3 p.Phe574Ser Uncertain significance Single submitter
- RASGRP3 p.Ser565Trp Uncertain significance Single submitter
- RASGRP3 p.Tyr432Cys Uncertain significance Single submitter
All RASGRP3 variants
Benign 1
- p.Ser139= Single submitter
Likely benign 5
- p.Arg60Gln Single submitter
- p.Ile301= Single submitter
- p.Phe77= Single submitter
- p.Thr501= Single submitter
- p.Val115Ile Single submitter
Uncertain significance 69
- p.Ala229Thr Single submitter
- p.Ala548Thr Single submitter ⚠
- p.Ala550Val Single submitter ⚠
- p.Ala644Val Single submitter ⚠
- p.Ala651Ser Single submitter ⚠
- p.Arg255His Single submitter ⚠
- p.Arg545Lys Single submitter ⚠
- p.Arg549Gln Single submitter ⚠
- p.Arg584Gly Single submitter ⚠
- p.Arg599Cys Single submitter ⚠
- p.Arg599His Single submitter ⚠
- p.Arg669Gln Single submitter ⚠
- p.Arg669Trp Single submitter ⚠
- p.Asn227Ser Single submitter ⚠
- p.Asn272Ser Single submitter ⚠
- p.Asn286His Single submitter ⚠
- p.Asn286Ser Single submitter ⚠
- p.Asn345Ile Single submitter ⚠
- p.Asn358Ile Single submitter
- p.Asn418Lys Single submitter ⚠
- p.Asn496Ser Single submitter ⚠
- p.Asn531Ser Single submitter ⚠
- p.Asp293Asn Single submitter ⚠
- p.Asp371His Single submitter ⚠
- p.Asp456Asn Single submitter
- p.Asp647Glu Single submitter ⚠
- p.Asp668Val Single submitter ⚠
- p.Asp678Glu Single submitter ⚠
- p.Cys536Arg Single submitter ⚠
- p.Cys57Gly Single submitter ⚠
- p.Cys67Phe Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.His150Arg Single submitter ⚠
- p.His165Arg Single submitter
- p.His165Asp Single submitter ⚠
- p.His486Arg Single submitter ⚠
- p.His557Arg Single submitter ⚠
- p.His661Arg Single submitter ⚠
- p.Ile226Val Single submitter ⚠
- p.Ile301Thr Single submitter ⚠
- p.Ile518Leu Single submitter ⚠
- p.Leu117Phe Single submitter ⚠
- p.Leu360Pro Single submitter ⚠
- p.Leu6Phe Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Lys289Arg Single submitter ⚠
- p.Lys411Thr Single submitter ⚠
- p.Lys488Glu Single submitter ⚠
- p.Met129Ile Single submitter ⚠
- p.Met474Leu Single submitter
- p.Met500Ile Single submitter
- p.Met58Ile Single submitter ⚠
- p.Phe297Leu Single submitter ⚠
- p.Phe574Ser Single submitter ⚠
- p.Pro153Ser Single submitter
- p.Pro382Ala Single submitter ⚠
- p.Ser139Pro Single submitter ⚠
- p.Ser252Tyr Single submitter ⚠
- p.Ser565Trp Single submitter ⚠
- p.Ser598Pro Single submitter ⚠
- p.Thr214Ile Single submitter ⚠
- p.Thr415Lys Single submitter ⚠
- p.Thr506Ile Single submitter ⚠
- p.Tyr432Cys Single submitter ⚠
- p.Tyr80Cys Single submitter
- p.Val209Ile Single submitter ⚠
- p.Val244Met Single submitter ⚠
- p.Val594Ile Single submitter ⚠
- p.Val660Leu Single submitter ⚠