RASSF2 — 48 ClinVar variants
All ClinVar germline RASSF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Likely benign · 47 Uncertain significance
Full RASSF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RASSF2 p.Ala237Ser Uncertain significance Single submitter
- RASSF2 p.Arg144Cys Uncertain significance Single submitter
- RASSF2 p.Arg152His Uncertain significance Single submitter
- RASSF2 p.Arg162Gln Uncertain significance Single submitter
- RASSF2 p.Arg303His Uncertain significance Single submitter
- RASSF2 p.Arg42Trp Uncertain significance Single submitter
- RASSF2 p.Arg67Cys Uncertain significance Single submitter
- RASSF2 p.Arg76His Uncertain significance Single submitter
- RASSF2 p.Asn196Ser Uncertain significance Single submitter
- RASSF2 p.Asp113Asn Uncertain significance Single submitter
- RASSF2 p.Cys12Arg Uncertain significance Single submitter
- RASSF2 p.Glu111Asp Uncertain significance Single submitter
- RASSF2 p.Glu49Asp Uncertain significance Single submitter
- RASSF2 p.Gly188Val Uncertain significance Single submitter
- RASSF2 p.His5Tyr Uncertain significance Single submitter
- RASSF2 p.Ile319Leu Uncertain significance Single submitter
- RASSF2 p.Leu92Met Uncertain significance Single submitter
- RASSF2 p.Lys106Arg Uncertain significance Single submitter
- RASSF2 p.Met280Lys Uncertain significance Single submitter
- RASSF2 p.Phe258Leu Uncertain significance Single submitter
- RASSF2 p.Pro115Leu Uncertain significance Single submitter
- RASSF2 p.Pro202Ser Uncertain significance Single submitter
- RASSF2 p.Pro281Leu Uncertain significance Single submitter
- RASSF2 p.Ser4Gly Uncertain significance Single submitter
- RASSF2 p.Ser8Phe Uncertain significance Single submitter
- RASSF2 p.Thr103Ser Uncertain significance Single submitter
- RASSF2 p.Thr125Pro Uncertain significance Single submitter
- RASSF2 p.Thr7Met Uncertain significance Single submitter
- RASSF2 p.Thr97Ile Uncertain significance Single submitter
- RASSF2 p.Tyr275Cys Uncertain significance Single submitter
- RASSF2 p.Tyr30Cys Uncertain significance Single submitter
- RASSF2 p.Val10Ile Uncertain significance Single submitter
- RASSF2 p.Val149Met Uncertain significance Single submitter
- RASSF2 p.Val193Ile Uncertain significance Single submitter
- RASSF2 p.Val307Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- RASSF2 p.Arg150Cys Uncertain significance Single submitter
- RASSF2 p.Arg151Cys Uncertain significance Single submitter
- RASSF2 p.Arg162Trp Uncertain significance Single submitter
- RASSF2 p.Arg194His Uncertain significance Single submitter
- RASSF2 p.Arg44Gly Uncertain significance Single submitter
- RASSF2 p.Arg64Gln Uncertain significance Single submitter
- RASSF2 p.Arg67His Uncertain significance Single submitter
- RASSF2 p.Gln37Pro Uncertain significance Single submitter
- RASSF2 p.Thr143Ala Uncertain significance Single submitter
- RASSF2 p.Thr157Met Uncertain significance Single submitter
All RASSF2 variants
Likely benign 1
- p.Lys304= Single submitter
Uncertain significance 47
- p.Ala237Ser Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg152His Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg166His Single submitter
- p.Arg194His Single submitter ⚠
- p.Arg303His Single submitter ⚠
- p.Arg42Trp Single submitter ⚠
- p.Arg44Gly Single submitter ⚠
- p.Arg64Gln Single submitter ⚠
- p.Arg67Cys Single submitter ⚠
- p.Arg67His Single submitter ⚠
- p.Arg76His Single submitter ⚠
- p.Asn196Ser Single submitter ⚠
- p.Asp113Asn Single submitter ⚠
- p.Cys12Arg Single submitter ⚠
- p.Gln37Pro Single submitter ⚠
- p.Glu111Asp Single submitter ⚠
- p.Glu49Asp Single submitter ⚠
- p.Gly188Val Single submitter ⚠
- p.His5Tyr Single submitter ⚠
- p.Ile319Leu Single submitter ⚠
- p.Leu92Met Single submitter ⚠
- p.Lys106Arg Single submitter ⚠
- p.Met280Lys Single submitter ⚠
- p.Phe258Leu Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro138Leu Single submitter
- p.Pro202Ser Single submitter ⚠
- p.Pro281Leu Single submitter ⚠
- p.Ser4Gly Single submitter ⚠
- p.Ser8Phe Single submitter ⚠
- p.Thr103Ser Single submitter ⚠
- p.Thr125Pro Single submitter ⚠
- p.Thr143Ala Single submitter ⚠
- p.Thr157Met Single submitter ⚠
- p.Thr7Met Single submitter ⚠
- p.Thr97Ile Single submitter ⚠
- p.Tyr275Cys Single submitter ⚠
- p.Tyr30Cys Single submitter ⚠
- p.Val10Ile Single submitter ⚠
- p.Val149Met Single submitter ⚠
- p.Val193Ile Single submitter ⚠
- p.Val307Met Single submitter ⚠