RASSF5 — 42 ClinVar variants
All ClinVar germline RASSF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Likely benign · 41 Uncertain significance
Full RASSF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RASSF5 p.Ala80Thr Uncertain significance Single submitter
- RASSF5 p.Arg178Gln Uncertain significance Single submitter
- RASSF5 p.Arg178Trp Uncertain significance Single submitter
- RASSF5 p.Arg204Cys Uncertain significance Single submitter
- RASSF5 p.Arg221Gln Uncertain significance Single submitter
- RASSF5 p.Arg247Gln Uncertain significance Single submitter
- RASSF5 p.Arg247Leu Uncertain significance Single submitter
- RASSF5 p.Arg323Gln Uncertain significance Single submitter
- RASSF5 p.Arg340His Uncertain significance Single submitter
- RASSF5 p.Arg75Gln Uncertain significance Single submitter
- RASSF5 p.Arg78Gly Uncertain significance Single submitter
- RASSF5 p.Arg81Gly Uncertain significance Single submitter
- RASSF5 p.Asp351Asn Uncertain significance Single submitter
- RASSF5 p.Asp390His Uncertain significance Single submitter
- RASSF5 p.Cys196Arg Uncertain significance Single submitter
- RASSF5 p.Gln172Lys Uncertain significance Single submitter
- RASSF5 p.Glu127Gly Uncertain significance Single submitter
- RASSF5 p.Ile324Leu Uncertain significance Single submitter
- RASSF5 p.Ile374Leu Uncertain significance Single submitter
- RASSF5 p.Lys397Asn Uncertain significance Single submitter
- RASSF5 p.Pro131Ala Uncertain significance Single submitter
- RASSF5 p.Pro249Leu Uncertain significance Single submitter
- RASSF5 p.Pro73Leu Uncertain significance Single submitter
- RASSF5 p.Pro79Ser Uncertain significance Single submitter
- RASSF5 p.Ser164Arg Uncertain significance Single submitter
- RASSF5 p.Thr190Ile Uncertain significance Single submitter
- RASSF5 p.Thr220Met Uncertain significance Single submitter
- RASSF5 p.Thr273Ile Uncertain significance Single submitter
- RASSF5 p.Thr297Ile Uncertain significance Single submitter
- RASSF5 p.Thr352Met Uncertain significance Single submitter
- RASSF5 p.Val115Gly Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- RASSF5 p.Arg114Ile Uncertain significance Single submitter
- RASSF5 p.Arg163Cys Uncertain significance Single submitter
- RASSF5 p.Asp112Glu Uncertain significance Single submitter
- RASSF5 p.Glu210Lys Uncertain significance Single submitter
- RASSF5 p.Gly122Glu Uncertain significance Single submitter
- RASSF5 p.Gly255Arg Uncertain significance Single submitter
- RASSF5 p.Lys322Glu Uncertain significance Single submitter
- RASSF5 p.Tyr262Cys Uncertain significance Single submitter
- RASSF5 p.Val367Leu Uncertain significance Single submitter
All RASSF5 variants
Likely benign 1
- p.Ile337Val Single submitter
Uncertain significance 41
- p.Ala80Thr Single submitter ⚠
- p.Arg114Ile Single submitter ⚠
- p.Arg163Cys Single submitter ⚠
- p.Arg178Gln Single submitter ⚠
- p.Arg178Trp Single submitter ⚠
- p.Arg204Cys Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg247Gln Single submitter ⚠
- p.Arg247Leu Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg340His Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Arg78Gly Single submitter ⚠
- p.Arg81Gly Single submitter ⚠
- p.Asp112Glu Single submitter ⚠
- p.Asp351Asn Single submitter ⚠
- p.Asp390His Single submitter ⚠
- p.Cys196Arg Single submitter ⚠
- p.Gln172Lys Single submitter ⚠
- p.Glu127Gly Single submitter ⚠
- p.Glu210Lys Single submitter ⚠
- p.Glu366Ala Single submitter
- p.Gly122Glu Single submitter ⚠
- p.Gly255Arg Single submitter ⚠
- p.Ile324Leu Single submitter ⚠
- p.Ile374Leu Single submitter ⚠
- p.Lys322Glu Single submitter ⚠
- p.Lys397Asn Single submitter ⚠
- p.Pro131Ala Single submitter ⚠
- p.Pro249Leu Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Pro79Ser Single submitter ⚠
- p.Ser164Arg Single submitter ⚠
- p.Thr190Ile Single submitter ⚠
- p.Thr220Met Single submitter ⚠
- p.Thr273Ile Single submitter ⚠
- p.Thr297Ile Single submitter ⚠
- p.Thr352Met Single submitter ⚠
- p.Tyr262Cys Single submitter ⚠
- p.Val115Gly Single submitter ⚠
- p.Val367Leu Single submitter ⚠