RAVER1 — 128 ClinVar variants

All ClinVar germline RAVER1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →

1 Benign · 1 Likely benign · 126 Uncertain significance

Full RAVER1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 87

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 72

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 15

The independent predictors disagree with each other — read with care.

All RAVER1 variants

Benign 1

p.Pro466= Multiple submitters

Likely benign 1

p.Asn372Ser Single submitter

Uncertain significance 126

c.14C>G Single submitter
c.17G>A Single submitter
c.-19A>C Single submitter
c.-21G>C Single submitter
p.Ala109Val Single submitter ⚠
p.Ala237Thr Single submitter ⚠
p.Ala241Val Single submitter ⚠
p.Ala265Thr Single submitter ⚠
p.Ala265Val Single submitter ⚠
p.Ala282Val Single submitter ⚠
p.Ala298Val Single submitter ⚠
p.Ala309Thr Single submitter ⚠
p.Ala341Ser Single submitter ⚠
p.Ala341Thr Single submitter ⚠
p.Ala355Val Single submitter ⚠
p.Ala526Val Single submitter
p.Ala532Thr Single submitter Inborn genetic diseases
p.Ala729Val Single submitter ⚠
p.Ala96Gly Single submitter ⚠
p.Arg10Trp Single submitter ⚠
p.Arg121Cys Single submitter ⚠
p.Arg121His Single submitter ⚠
p.Arg168His Single submitter ⚠
p.Arg188Cys Single submitter ⚠
p.Arg240Trp Single submitter ⚠
p.Arg304Cys Single submitter ⚠
p.Arg320Gln Single submitter ⚠
p.Arg431Gln Single submitter ⚠
p.Arg431Trp Single submitter ⚠
p.Arg450Trp Single submitter ⚠
p.Arg472Gln Single submitter ⚠
p.Arg472Ter Single submitter
p.Arg503Gln Single submitter
p.Arg527Gln Single submitter
p.Arg564Cys Single submitter
p.Arg56Cys Single submitter ⚠
p.Arg573His Single submitter
p.Arg58Gly Single submitter ⚠
p.Arg595Leu Single submitter
p.Arg595Trp Single submitter
p.Arg602Gln Single submitter
p.Arg613Gln Single submitter
p.Arg613Leu Single submitter
p.Arg626Leu Single submitter
p.Arg626Trp Single submitter
p.Arg699Cys Single submitter
p.Asn329Ser Single submitter ⚠
p.Asn520Ile Single submitter
p.Asp192Ala Single submitter ⚠
p.Asp234Asn Single submitter ⚠
p.Asp587Asn Single submitter
p.Gln171Arg Single submitter ⚠
p.Gln314Glu Single submitter ⚠
p.Gln386Arg Single submitter ⚠
p.Gln390Arg Single submitter ⚠
p.Glu107Lys Single submitter ⚠
p.Glu149Lys Single submitter ⚠
p.Glu150Val Single submitter ⚠
p.Glu20Gln Single submitter ⚠
p.Glu20Lys Single submitter ⚠
p.Glu277Lys Single submitter ⚠
p.Glu35Asp Single submitter ⚠
p.Glu709Lys Single submitter
p.Glu83Gln Single submitter ⚠
p.Gly103Trp Single submitter ⚠
p.Gly263Ser Single submitter ⚠
p.Gly284Ser Single submitter ⚠
p.Gly356Val Single submitter ⚠
p.Gly363Arg Single submitter ⚠
p.Gly363Val Single submitter ⚠
p.Gly394Ser Single submitter ⚠
p.Gly416Glu Single submitter ⚠
p.Gly444Val Single submitter ⚠
p.Gly533Arg Single submitter
p.Gly629Ser Single submitter
p.Gly673Arg Single submitter ⚠
p.Gly678Asp Single submitter ⚠
p.Gly68Glu Single submitter ⚠
p.Gly696Ser Single submitter
p.Gly725Ser Single submitter
p.His614Arg Single submitter
p.His9Tyr Single submitter ⚠
p.Ile330Met Single submitter ⚠
p.Leu151Val Single submitter ⚠
p.Leu415Val Single submitter ⚠
p.Leu566Pro Single submitter
p.Leu597Pro Single submitter
p.Leu62Gln Single submitter ⚠
p.Leu724Phe Single submitter
p.Lys16Arg Single submitter ⚠
p.Lys481Arg Single submitter
p.Lys60Asn Single submitter ⚠
p.Lys657Gln Single submitter ⚠
p.Met616Val Single submitter
p.Phe739Ser Single submitter
p.Pro11Leu Single submitter ⚠
p.Pro140Ser Single submitter ⚠
p.Pro366Gln Single submitter ⚠
p.Pro369Leu Single submitter ⚠
p.Pro425Ser Single submitter ⚠
p.Pro426Leu Single submitter ⚠
p.Pro430Arg Single submitter ⚠
p.Pro465His Single submitter ⚠
p.Pro619Ser Single submitter
p.Pro619Thr Single submitter
p.Ser124Leu Single submitter ⚠
p.Ser142Cys Single submitter ⚠
p.Ser142Gly Single submitter ⚠
p.Ser166Gly Single submitter ⚠
p.Ser191Leu Single submitter ⚠
p.Ser305Cys Single submitter
p.Ser342Pro Single submitter ⚠
p.Ser474Cys Single submitter ⚠
p.Ser621Arg Single submitter
p.Ser643Leu Single submitter ⚠
p.Ser700Arg Single submitter ⚠
p.Ser707Leu Single submitter ⚠
p.Thr130Met Single submitter ⚠
p.Thr208Met Single submitter ⚠
p.Thr316Met Single submitter ⚠
p.Thr378Met Single submitter ⚠
p.Thr488Met Single submitter
p.Thr95Arg Single submitter ⚠
p.Tyr640His Single submitter ⚠
p.Tyr732His Single submitter
p.Val442Met Single submitter ⚠