RBM15 — 65 ClinVar variants
All ClinVar germline RBM15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
3 Benign · 1 Likely benign · 61 Uncertain significance
Full RBM15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RBM15 p.Ser158Ala Uncertain significance Multiple submitters
- RBM15 p.Ala275Val Uncertain significance Single submitter
- RBM15 p.Ala298Thr Uncertain significance Single submitter
- RBM15 p.Ala355Thr Uncertain significance Single submitter
- RBM15 p.Ala557Thr Uncertain significance Single submitter
- RBM15 p.Arg152Leu Uncertain significance Single submitter
- RBM15 p.Arg594Gln Uncertain significance Single submitter
- RBM15 p.Asn798Ser Uncertain significance Single submitter
- RBM15 p.Asp485Gly Uncertain significance Single submitter
- RBM15 p.Asp868Asn Uncertain significance Single submitter
- RBM15 p.Gln930Arg Uncertain significance Single submitter
- RBM15 p.Glu330Asp Uncertain significance Single submitter
- RBM15 p.Glu547Gln Uncertain significance Single submitter
- RBM15 p.Gly138Ser Uncertain significance Single submitter
- RBM15 p.Gly296Val Uncertain significance Single submitter
- RBM15 p.His206Arg Uncertain significance Single submitter
- RBM15 p.His282Asn Uncertain significance Single submitter
- RBM15 p.His282Tyr Uncertain significance Single submitter
- RBM15 p.His555Leu Uncertain significance Single submitter
- RBM15 p.Ile438Val Uncertain significance Single submitter
- RBM15 p.Ile831Met Uncertain significance Single submitter
- RBM15 p.Leu207Val Uncertain significance Single submitter
- RBM15 p.Leu548Val Uncertain significance Single submitter
- RBM15 p.Leu580Val Uncertain significance Single submitter
- RBM15 p.Leu860Arg Uncertain significance Single submitter
- RBM15 p.Lys132Arg Uncertain significance Single submitter
- RBM15 p.Lys825Thr Uncertain significance Single submitter
- RBM15 p.Pro267Ser Uncertain significance Single submitter
- RBM15 p.Pro268Leu Uncertain significance Single submitter
- RBM15 p.Pro320Leu Uncertain significance Single submitter
- RBM15 p.Pro357Ser Uncertain significance Single submitter
- RBM15 p.Pro443Ser Uncertain significance Single submitter
- RBM15 p.Pro467Ser Uncertain significance Single submitter
- RBM15 p.Pro542Ser Uncertain significance Single submitter
- RBM15 p.Pro560Leu Uncertain significance Single submitter
- RBM15 p.Pro589Ser Uncertain significance Single submitter
- RBM15 p.Pro592Leu Uncertain significance Single submitter
- RBM15 p.Ser134Tyr Uncertain significance Single submitter
- RBM15 p.Ser142Arg Uncertain significance Single submitter
- RBM15 p.Ser208Ala Uncertain significance Single submitter
- RBM15 p.Ser388Ile Uncertain significance Single submitter
- RBM15 p.Thr452Ile Uncertain significance Single submitter
- RBM15 p.Thr508Ile Uncertain significance Single submitter
- RBM15 p.Thr882Ile Uncertain significance Single submitter
- RBM15 p.Val851Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- RBM15 p.Arg237Cys Uncertain significance Single submitter
- RBM15 p.Arg255Cys Uncertain significance Single submitter
- RBM15 p.Arg96Pro Uncertain significance Single submitter
- RBM15 p.Asp326Gly Uncertain significance Single submitter
- RBM15 p.Asp566Gly Uncertain significance Single submitter
- RBM15 p.His509Arg Uncertain significance Single submitter
- RBM15 p.Ile904Val Uncertain significance Single submitter
- RBM15 p.Leu792Ile Uncertain significance Single submitter
- RBM15 p.Lys102Glu Uncertain significance Single submitter
- RBM15 p.Lys203Thr Uncertain significance Single submitter
- RBM15 p.Met791Ile Uncertain significance Single submitter
- RBM15 p.Ser153Phe Uncertain significance Single submitter
- RBM15 p.Ser388Arg Uncertain significance Single submitter
- RBM15 p.Tyr336Cys Uncertain significance Single submitter
All RBM15 variants
Likely benign 1
- p.Ala557Val Single submitter
Uncertain significance 61
- p.Ser158Ala Multiple submitters ⚠
- p.Ala275Val Single submitter ⚠
- p.Ala298Thr Single submitter ⚠
- p.Ala355Thr Single submitter ⚠
- p.Ala557Thr Single submitter ⚠
- p.Arg152Leu Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Arg255Cys Single submitter ⚠
- p.Arg594Gln Single submitter ⚠
- p.Arg96Pro Single submitter ⚠
- p.Asn798Ser Single submitter ⚠
- p.Asp326Gly Single submitter ⚠
- p.Asp485Gly Single submitter ⚠
- p.Asp566Gly Single submitter ⚠
- p.Asp868Asn Single submitter ⚠
- p.Gln930Arg Single submitter ⚠
- p.Glu330Asp Single submitter ⚠
- p.Glu547Gln Single submitter ⚠
- p.Gly138Ser Single submitter ⚠
- p.Gly296Val Single submitter ⚠
- p.His206Arg Single submitter ⚠
- p.His282Asn Single submitter ⚠
- p.His282Tyr Single submitter ⚠
- p.His509Arg Single submitter ⚠
- p.His555Leu Single submitter ⚠
- p.Ile438Val Single submitter ⚠
- p.Ile831Met Single submitter ⚠
- p.Ile904Val Single submitter ⚠
- p.Leu207Val Single submitter ⚠
- p.Leu548Val Single submitter ⚠
- p.Leu580Val Single submitter ⚠
- p.Leu792Ile Single submitter ⚠
- p.Leu860Arg Single submitter ⚠
- p.Lys102Glu Single submitter ⚠
- p.Lys132Arg Single submitter ⚠
- p.Lys203Thr Single submitter ⚠
- p.Lys825Thr Single submitter ⚠
- p.Met791Ile Single submitter ⚠
- p.Pro267Ser Single submitter ⚠
- p.Pro268Leu Single submitter ⚠
- p.Pro320Leu Single submitter ⚠
- p.Pro357Ser Single submitter ⚠
- p.Pro443Ser Single submitter ⚠
- p.Pro467Ser Single submitter ⚠
- p.Pro542Ser Single submitter ⚠
- p.Pro560Leu Single submitter ⚠
- p.Pro589Ser Single submitter ⚠
- p.Pro592Leu Single submitter ⚠
- p.Ser134Tyr Single submitter ⚠
- p.Ser142Arg Single submitter ⚠
- p.Ser153Phe Single submitter ⚠
- p.Ser208Ala Single submitter ⚠
- p.Ser388Arg Single submitter ⚠
- p.Ser388Ile Single submitter ⚠
- p.Thr452Ile Single submitter ⚠
- p.Thr508Ile Single submitter ⚠
- p.Thr882Ile Single submitter ⚠
- p.Trp586Leu Single submitter
- p.Tyr336Cys Single submitter ⚠
- p.Val851Ala Single submitter ⚠
- p.Val962fs Single submitter orofacial cleft