RBM25 — 45 ClinVar variants
All ClinVar germline RBM25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Likely benign · 44 Uncertain significance
Full RBM25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RBM25 p.Ala167Ser Uncertain significance Single submitter
- RBM25 p.Ala490Thr Uncertain significance Single submitter
- RBM25 p.Arg202Lys Uncertain significance Single submitter
- RBM25 p.Arg377His Uncertain significance Single submitter
- RBM25 p.Arg381His Uncertain significance Single submitter
- RBM25 p.Asn378Ser Uncertain significance Single submitter
- RBM25 p.Asn652Ser Uncertain significance Single submitter
- RBM25 p.Asn676Ser Uncertain significance Single submitter
- RBM25 p.Asn8Thr Uncertain significance Single submitter
- RBM25 p.Asp230Glu Uncertain significance Single submitter
- RBM25 p.Cys612Tyr Uncertain significance Single submitter
- RBM25 p.Glu660Gly Uncertain significance Single submitter
- RBM25 p.His662Arg Uncertain significance Single submitter
- RBM25 p.Ile244Met Uncertain significance Single submitter
- RBM25 p.Ile577Leu Uncertain significance Single submitter
- RBM25 p.Ile577Val Uncertain significance Single submitter
- RBM25 p.Ile94Val Uncertain significance Single submitter
- RBM25 p.Lys97Arg Uncertain significance Single submitter
- RBM25 p.Met12Thr Uncertain significance Single submitter
- RBM25 p.Pro49Ser Uncertain significance Single submitter
- RBM25 p.Pro750Ala Uncertain significance Single submitter
- RBM25 p.Ser382Gly Uncertain significance Single submitter
- RBM25 p.Ser622Pro Uncertain significance Single submitter
- RBM25 p.Ser627Ala Uncertain significance Single submitter
- RBM25 p.Thr728Pro Uncertain significance Single submitter
- RBM25 p.Thr86Ala Uncertain significance Single submitter
- RBM25 p.Val706Ile Uncertain significance Single submitter
- RBM25 p.Val842Gly Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- RBM25 p.Arg361Gln Uncertain significance Single submitter
- RBM25 p.Arg407Gln Uncertain significance Single submitter
- RBM25 p.Arg411Trp Uncertain significance Single submitter
- RBM25 p.Arg413Gln Uncertain significance Single submitter
- RBM25 p.Arg421Pro Uncertain significance Single submitter
- RBM25 p.Arg421Trp Uncertain significance Single submitter
- RBM25 p.Arg487Thr Uncertain significance Single submitter
- RBM25 p.Arg523Cys Uncertain significance Single submitter
- RBM25 p.Arg523His Uncertain significance Single submitter
- RBM25 p.Glu406Gln Uncertain significance Single submitter
- RBM25 p.Glu566Lys Uncertain significance Single submitter
- RBM25 p.Gly667Glu Uncertain significance Single submitter
- RBM25 p.Lys427Glu Uncertain significance Single submitter
- RBM25 p.Met39Thr Uncertain significance Single submitter
- RBM25 p.Tyr441Asp Uncertain significance Single submitter
All RBM25 variants
Likely benign 1
- p.Met601Val Single submitter
Uncertain significance 44
- p.Ala167Ser Single submitter ⚠
- p.Ala490Thr Single submitter ⚠
- p.Arg202Lys Single submitter ⚠
- p.Arg361Gln Single submitter ⚠
- p.Arg377His Single submitter ⚠
- p.Arg381His Single submitter ⚠
- p.Arg407Gln Single submitter ⚠
- p.Arg411Trp Single submitter ⚠
- p.Arg413Gln Single submitter ⚠
- p.Arg421Pro Single submitter ⚠
- p.Arg421Trp Single submitter ⚠
- p.Arg487Thr Single submitter ⚠
- p.Arg523Cys Single submitter ⚠
- p.Arg523His Single submitter ⚠
- p.Asn378Ser Single submitter ⚠
- p.Asn652Ser Single submitter ⚠
- p.Asn676Ser Single submitter ⚠
- p.Asn8Thr Single submitter ⚠
- p.Asp230Glu Single submitter ⚠
- p.Cys612Tyr Single submitter ⚠
- p.Glu406Gln Single submitter ⚠
- p.Glu566Lys Single submitter ⚠
- p.Glu660Gly Single submitter ⚠
- p.Gly667Glu Single submitter ⚠
- p.His662Arg Single submitter ⚠
- p.Ile244Met Single submitter ⚠
- p.Ile577Leu Single submitter ⚠
- p.Ile577Val Single submitter ⚠
- p.Ile94Val Single submitter ⚠
- p.Lys295fs Single submitter
- p.Lys427Glu Single submitter ⚠
- p.Lys97Arg Single submitter ⚠
- p.Met12Thr Single submitter ⚠
- p.Met39Thr Single submitter ⚠
- p.Pro49Ser Single submitter ⚠
- p.Pro750Ala Single submitter ⚠
- p.Ser382Gly Single submitter ⚠
- p.Ser622Pro Single submitter ⚠
- p.Ser627Ala Single submitter ⚠
- p.Thr728Pro Single submitter ⚠
- p.Thr86Ala Single submitter ⚠
- p.Tyr441Asp Single submitter ⚠
- p.Val706Ile Single submitter ⚠
- p.Val842Gly Single submitter ⚠