Sugi Variant

Sugi Variant/RBM28

RBM28 — 151 ClinVar variants

All ClinVar germline RBM28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →

2 Pathogenic · 2 Likely pathogenic · 1 Conflicting · 7 Benign · 3 Benign/Likely benign · 33 Likely benign · 103 Uncertain significance

Full RBM28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 98

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 72

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 24

The independent predictors disagree with each other — read with care.

All RBM28 variants

Pathogenic 2

Likely pathogenic 2

Conflicting classifications of pathogenicity 1

Benign 7

Benign/Likely benign 3

Likely benign 33

Uncertain significance 103