RBM3 — 11 ClinVar variants
All ClinVar germline RBM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
11 Uncertain significance
Full RBM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RBM3 p.Arg41Trp Uncertain significance Single submitter
- RBM3 p.Arg90Gly Uncertain significance Single submitter
- RBM3 p.Gly95Ala Uncertain significance Single submitter
- RBM3 p.His97Leu Uncertain significance Single submitter
- RBM3 p.Tyr103His Uncertain significance Single submitter
- RBM3 p.Tyr129Cys Uncertain significance Single submitter
- RBM3 p.Tyr135Ser Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RBM3 variants
Uncertain significance 11
- p.Arg41Trp Single submitter ⚠
- p.Arg90Gly Single submitter ⚠
- p.Gly124Arg Single submitter ⚠
- p.Gly95Ala Single submitter ⚠
- p.His97Leu Single submitter ⚠
- p.Tyr103Cys Single submitter ⚠
- p.Tyr103His Single submitter ⚠
- p.Tyr112Cys Single submitter ⚠
- p.Tyr129Cys Single submitter ⚠
- p.Tyr135Ser Single submitter ⚠
- p.Tyr155His Single submitter ⚠