RCC2 — 48 ClinVar variants
All ClinVar germline RCC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
48 Uncertain significance
Full RCC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RCC2 p.Ala146Glu Uncertain significance Single submitter
- RCC2 p.Ala6Val Uncertain significance Single submitter
- RCC2 p.Ala78Thr Uncertain significance Single submitter
- RCC2 p.Ala7Gly Uncertain significance Single submitter
- RCC2 p.Ala9Thr Uncertain significance Single submitter
- RCC2 p.Arg149Gln Uncertain significance Single submitter
- RCC2 p.Arg310Gln Uncertain significance Single submitter
- RCC2 p.Arg350Gly Uncertain significance Single submitter
- RCC2 p.Arg94His Uncertain significance Single submitter
- RCC2 p.Asn18Tyr Uncertain significance Single submitter
- RCC2 p.Glu13Asp Uncertain significance Single submitter
- RCC2 p.Gly17Ala Uncertain significance Single submitter
- RCC2 p.Gly403Val Uncertain significance Single submitter
- RCC2 p.Gly61Trp Uncertain significance Single submitter
- RCC2 p.Gly66Asp Uncertain significance Single submitter
- RCC2 p.Gly66Cys Uncertain significance Single submitter
- RCC2 p.Gly80Asp Uncertain significance Single submitter
- RCC2 p.Gly80Cys Uncertain significance Single submitter
- RCC2 p.His213Tyr Uncertain significance Single submitter
- RCC2 p.Ile196Val Uncertain significance Single submitter
- RCC2 p.Ile256Val Uncertain significance Single submitter
- RCC2 p.Ile314Val Uncertain significance Single submitter
- RCC2 p.Lys513Glu Uncertain significance Single submitter
- RCC2 p.Lys96Gln Uncertain significance Single submitter
- RCC2 p.Phe352Ser Uncertain significance Single submitter
- RCC2 p.Pro14Arg Uncertain significance Single submitter
- RCC2 p.Pro309Ala Uncertain significance Single submitter
- RCC2 p.Ser16Ala Uncertain significance Single submitter
- RCC2 p.Ser434Ile Uncertain significance Single submitter
- RCC2 p.Thr220Met Uncertain significance Single submitter
- RCC2 p.Thr74Ile Uncertain significance Single submitter
- RCC2 p.Tyr276Cys Uncertain significance Single submitter
- RCC2 p.Val223Met Uncertain significance Single submitter
- RCC2 p.Val83Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- RCC2 p.Ala490Thr Uncertain significance Single submitter
- RCC2 p.Asp115Asn Uncertain significance Single submitter
- RCC2 p.Gln425His Uncertain significance Single submitter
- RCC2 p.Gly143Glu Uncertain significance Single submitter
- RCC2 p.Ile295Val Uncertain significance Single submitter
- RCC2 p.Ile316Thr Uncertain significance Single submitter
- RCC2 p.Leu163Phe Uncertain significance Single submitter
- RCC2 p.Ser504Arg Uncertain significance Single submitter
- RCC2 p.Trp11Arg Uncertain significance Single submitter
- RCC2 p.Tyr129His Uncertain significance Single submitter
- RCC2 p.Tyr393Cys Uncertain significance Single submitter
-
RCC2 p.Cys261Ser
Uncertain significance
No assertion criteria
prostate cancer
All RCC2 variants
Uncertain significance 48
- p.Ala146Glu Single submitter ⚠
- p.Ala490Thr Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala78Thr Single submitter ⚠
- p.Ala7Gly Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg149Gln Single submitter ⚠
- p.Arg151Trp Single submitter
- p.Arg310Gln Single submitter ⚠
- p.Arg350Gly Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Asn18Tyr Single submitter ⚠
- p.Asp115Asn Single submitter ⚠
- p.Gln425His Single submitter ⚠
- p.Glu13Asp Single submitter ⚠
- p.Gly143Glu Single submitter ⚠
- p.Gly17Ala Single submitter ⚠
- p.Gly403Val Single submitter ⚠
- p.Gly61Trp Single submitter ⚠
- p.Gly66Asp Single submitter ⚠
- p.Gly66Cys Single submitter ⚠
- p.Gly80Asp Single submitter ⚠
- p.Gly80Cys Single submitter ⚠
- p.His213Tyr Single submitter ⚠
- p.Ile196Val Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Ile295Val Single submitter ⚠
- p.Ile314Val Single submitter ⚠
- p.Ile316Thr Single submitter ⚠
- p.Leu163Phe Single submitter ⚠
- p.Lys513Glu Single submitter ⚠
- p.Lys96Gln Single submitter ⚠
- p.Phe352Ser Single submitter ⚠
- p.Pro14Arg Single submitter ⚠
- p.Pro309Ala Single submitter ⚠
- p.Ser16Ala Single submitter ⚠
- p.Ser434Ile Single submitter ⚠
- p.Ser504Arg Single submitter ⚠
- p.Thr220Met Single submitter ⚠
- p.Thr74Ile Single submitter ⚠
- p.Trp11Arg Single submitter ⚠
- p.Tyr129His Single submitter ⚠
- p.Tyr276Cys Single submitter ⚠
- p.Tyr393Cys Single submitter ⚠
- p.Val223Met Single submitter ⚠
- p.Val243Leu Single submitter
- p.Val83Ala Single submitter ⚠
- p.Cys261Ser No assertion criteria prostate cancer ⚠