RCOR3 — 46 ClinVar variants
All ClinVar germline RCOR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Likely benign · 43 Uncertain significance
Full RCOR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RCOR3 p.Ala455Ser Uncertain significance Single submitter
- RCOR3 p.Ala517Thr Uncertain significance Single submitter
- RCOR3 p.Ala63Gly Uncertain significance Single submitter
- RCOR3 p.Arg203Cys Uncertain significance Single submitter
- RCOR3 p.Arg274Cys Uncertain significance Single submitter
- RCOR3 p.Arg312His Uncertain significance Single submitter
- RCOR3 p.Arg447Gln Uncertain significance Single submitter
- RCOR3 p.Arg447Trp Uncertain significance Single submitter
- RCOR3 p.Asn294Ser Uncertain significance Single submitter
- RCOR3 p.Asn412Lys Uncertain significance Single submitter
- RCOR3 p.Asp366Val Uncertain significance Single submitter
- RCOR3 p.Gly241Val Uncertain significance Single submitter
- RCOR3 p.Gly75Asp Uncertain significance Single submitter
- RCOR3 p.His126Tyr Uncertain significance Single submitter
- RCOR3 p.Ile252Thr Uncertain significance Single submitter
- RCOR3 p.Ile466Val Uncertain significance Single submitter
- RCOR3 p.Lys234Gln Uncertain significance Single submitter
- RCOR3 p.Lys272Arg Uncertain significance Single submitter
- RCOR3 p.Phe393Cys Uncertain significance Single submitter
- RCOR3 p.Pro293Ser Uncertain significance Single submitter
- RCOR3 p.Thr243Asn Uncertain significance Single submitter
- RCOR3 p.Thr532Met Uncertain significance Single submitter
- RCOR3 p.Val218Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- RCOR3 p.Arg274His Uncertain significance Single submitter
- RCOR3 p.Arg488Gln Uncertain significance Single submitter
- RCOR3 p.Arg515Pro Uncertain significance Single submitter
- RCOR3 p.Asn297Ile Uncertain significance Single submitter
- RCOR3 p.Asp175Glu Uncertain significance Single submitter
- RCOR3 p.Ile299Val Uncertain significance Single submitter
- RCOR3 p.Leu303Val Uncertain significance Single submitter
- RCOR3 p.Lys272Glu Uncertain significance Single submitter
- RCOR3 p.Phe393Leu Uncertain significance Single submitter
- RCOR3 p.Pro472Leu Uncertain significance Single submitter
- RCOR3 p.Pro491Ser Uncertain significance Single submitter
- RCOR3 p.Pro512Leu Uncertain significance Single submitter
All RCOR3 variants
Uncertain significance 43
- p.Ala158Gly Single submitter
- p.Ala18Val Single submitter
- p.Ala22Thr Single submitter
- p.Ala455Ser Single submitter ⚠
- p.Ala517Thr Single submitter ⚠
- p.Ala63Gly Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg274Cys Single submitter ⚠
- p.Arg274His Single submitter ⚠
- p.Arg312His Single submitter ⚠
- p.Arg447Gln Single submitter ⚠
- p.Arg447Trp Single submitter ⚠
- p.Arg488Gln Single submitter ⚠
- p.Arg515Pro Single submitter ⚠
- p.Asn294Ser Single submitter ⚠
- p.Asn297Ile Single submitter ⚠
- p.Asn412Lys Single submitter ⚠
- p.Asp175Glu Single submitter ⚠
- p.Asp366Val Single submitter ⚠
- p.Asp83Ala Single submitter
- p.Gly13Arg Single submitter
- p.Gly20Asp Single submitter
- p.Gly241Val Single submitter ⚠
- p.Gly75Asp Single submitter ⚠
- p.His126Tyr Single submitter ⚠
- p.Ile252Thr Single submitter ⚠
- p.Ile299Val Single submitter ⚠
- p.Ile466Val Single submitter ⚠
- p.Leu303Val Single submitter ⚠
- p.Lys234Gln Single submitter ⚠
- p.Lys272Arg Single submitter ⚠
- p.Lys272Glu Single submitter ⚠
- p.Phe393Cys Single submitter ⚠
- p.Phe393Leu Single submitter ⚠
- p.Pro25Leu Single submitter
- p.Pro293Ser Single submitter ⚠
- p.Pro472Leu Single submitter ⚠
- p.Pro491Ser Single submitter ⚠
- p.Pro512Leu Single submitter ⚠
- p.Thr243Asn Single submitter ⚠
- p.Thr532Met Single submitter ⚠
- p.Tyr42Phe Single submitter
- p.Val218Ile Single submitter ⚠