REV1 — 150 ClinVar variants

All ClinVar germline REV1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 128 flagged for review →

1 Benign · 11 Likely benign · 138 Uncertain significance

Full REV1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 128

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 111

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 17

The independent predictors disagree with each other — read with care.

All REV1 variants

Benign 1

p.Leu1131His Multiple submitters

Likely benign 11

p.Asn1091Lys Single submitter
p.Asn1166Ser Single submitter
p.Asp262Glu Single submitter
p.Glu260= Single submitter
p.Gly1081Ser Single submitter
p.Met245Val Single submitter
p.Ser1143Gly Single submitter
p.Ser117= Single submitter
p.Ser882Pro Single submitter
p.Tyr850His Single submitter
p.Val172Ile Single submitter

Uncertain significance 138

p.Ala335Thr Single submitter ⚠
p.Ala494Val Single submitter ⚠
p.Ala581Gly Single submitter ⚠
p.Ala789Thr Single submitter ⚠
p.Ala907Asp Single submitter ⚠
p.Arg219Ser Single submitter ⚠
p.Arg290Gln Single submitter ⚠
p.Arg290Gly Single submitter ⚠
p.Arg290Trp Single submitter ⚠
p.Arg34Gln Single submitter ⚠
p.Arg458Cys Single submitter ⚠
p.Arg696His Single submitter ⚠
p.Arg752His Single submitter ⚠
p.Arg837Cys Single submitter ⚠
p.Arg853Cys Single submitter ⚠
p.Arg874Gln Single submitter ⚠
p.Asn184Ser Single submitter ⚠
p.Asn310Ser Single submitter ⚠
p.Asn373Asp Single submitter ⚠
p.Asn380His Single submitter ⚠
p.Asn435fs Single submitter
p.Asn462Ile Single submitter ⚠
p.Asn497Asp Single submitter ⚠
p.Asn802Lys Single submitter ⚠
p.Asn914Ser Single submitter ⚠
p.Asp13Asn Single submitter ⚠
p.Asp700Gly Single submitter
p.Asp778Gly Single submitter ⚠
p.Asp903His Single submitter ⚠
p.Asp968Asn Single submitter ⚠
p.Cys241Ser Single submitter ⚠
p.Cys274Ser Single submitter ⚠
p.Cys274Tyr Single submitter ⚠
p.Cys418Phe Single submitter ⚠
p.Cys418Tyr Single submitter
p.Cys511Arg Single submitter ⚠
p.Cys888Ser Single submitter ⚠
p.Gln139Arg Single submitter ⚠
p.Gln163Arg Single submitter ⚠
p.Gln205His Single submitter ⚠
p.Gln212Glu Single submitter ⚠
p.Gln280Glu Single submitter ⚠
p.Gln318Lys Single submitter ⚠
p.Gln857His Single submitter ⚠
p.Glu1125Asp Single submitter ⚠
p.Glu112Ala Single submitter ⚠
p.Glu112Lys Single submitter
p.Glu1164Ala Single submitter ⚠
p.Glu1222Gln Single submitter ⚠
p.Glu657Lys Single submitter ⚠
p.Glu715Gly Single submitter ⚠
p.Glu727Asp Single submitter ⚠
p.Glu944Ala Single submitter ⚠
p.Glu944Lys Single submitter ⚠
p.Gly1104Ala Single submitter ⚠
p.Gly1121Arg Single submitter ⚠
p.Gly156Arg Single submitter ⚠
p.Gly523Arg Single submitter ⚠
p.His1063Arg Single submitter ⚠
p.His293Gln Single submitter ⚠
p.His359Tyr Single submitter ⚠
p.His844Arg Single submitter ⚠
p.His844Asp Single submitter ⚠
p.His917Arg Single submitter ⚠
p.Ile1179Val Single submitter ⚠
p.Ile118Val Single submitter ⚠
p.Ile127Val Single submitter ⚠
p.Ile160Val Single submitter ⚠
p.Ile811Val Single submitter ⚠
p.Ile881Arg Single submitter ⚠
p.Leu465Pro Single submitter ⚠
p.Leu733Gln Single submitter ⚠
p.Lys1126Arg Single submitter ⚠
p.Lys134Thr Single submitter ⚠
p.Lys182Gln Single submitter ⚠
p.Lys263Gln Single submitter ⚠
p.Lys584Glu Single submitter ⚠
p.Lys599Glu Single submitter ⚠
p.Lys678Arg Single submitter ⚠
p.Lys808Glu Single submitter ⚠
p.Lys86Glu Single submitter
p.Lys8Arg Single submitter ⚠
p.Met1183Val Single submitter ⚠
p.Met186Ile Single submitter ⚠
p.Met22Val Single submitter ⚠
p.Met424Val Single submitter ⚠
p.Met72Ile Single submitter ⚠
p.Met807Val Single submitter ⚠
p.Phe1165Val Single submitter ⚠
p.Phe225Leu Single submitter ⚠
p.Phe683Leu Single submitter ⚠
p.Phe856Tyr Single submitter ⚠
p.Pro1060Thr Single submitter ⚠
p.Pro1083Leu Single submitter ⚠
p.Pro1122Ser Single submitter ⚠
p.Pro1127Thr Single submitter ⚠
p.Pro128Ala Single submitter ⚠
p.Pro155Leu Single submitter ⚠
p.Pro216Leu Single submitter ⚠
p.Pro437Ala Single submitter ⚠
p.Pro437Leu Single submitter ⚠
p.Pro765Ala Single submitter
p.Pro765Ser Single submitter ⚠
p.Pro899Leu Single submitter ⚠
p.Pro902His Single submitter ⚠
p.Pro902Ser Single submitter ⚠
p.Ser221Asn Single submitter ⚠
p.Ser282Ile Single submitter ⚠
p.Ser330Cys Single submitter ⚠
p.Ser333Arg Single submitter ⚠
p.Ser448Ile Single submitter ⚠
p.Ser493Ala Single submitter ⚠
p.Ser63Cys Single submitter ⚠
p.Ser658Pro Single submitter
p.Ser711Phe Single submitter ⚠
p.Ser83Cys Single submitter
p.Ser843Arg Single submitter ⚠
p.Ser847Thr Single submitter ⚠
p.Thr1135Ala Single submitter ⚠
p.Thr283Ser Single submitter ⚠
p.Thr295Ala Single submitter ⚠
p.Thr369Pro Single submitter
p.Thr621Ala Single submitter
p.Thr647Asn Single submitter ⚠
p.Thr647Ser Single submitter ⚠
p.Thr900Ile Single submitter ⚠
p.Tyr353Cys Single submitter ⚠
p.Val1152Glu Single submitter ⚠
p.Val1191Met Single submitter ⚠
p.Val138Glu Single submitter ⚠
p.Val243Met Single submitter ⚠
p.Val249Ile Single submitter ⚠
p.Val339Leu Single submitter ⚠
p.Val446Ile Single submitter ⚠
p.Val766Ile Single submitter ⚠
p.Val821Met Single submitter ⚠
p.Val922Met Single submitter ⚠
p.Val957Ile Single submitter ⚠