Sugi Variant

Sugi Variant/REV3L

REV3L — 429 ClinVar variants

All ClinVar germline REV3L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 251 flagged for review →

2 Pathogenic · 1 Likely pathogenic · 13 Conflicting · 46 Benign · 7 Benign/Likely benign · 75 Likely benign · 285 Uncertain significance

Full REV3L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 251

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 12

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 220

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 220

Predictors split 18

The independent predictors disagree with each other — read with care.

All REV3L variants

Pathogenic 2

Likely pathogenic 1

Conflicting classifications of pathogenicity 13

Benign 46

Benign/Likely benign 7

Likely benign 75

Uncertain significance 285