RFC3 — 41 ClinVar variants
All ClinVar germline RFC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
41 Uncertain significance
Full RFC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RFC3 p.Ala181Val Uncertain significance Single submitter
- RFC3 p.Ala186Thr Uncertain significance Single submitter
- RFC3 p.Ala334Val Uncertain significance Single submitter
- RFC3 p.Arg57Cys Uncertain significance Single submitter
- RFC3 p.Asn206Thr Uncertain significance Single submitter
- RFC3 p.Cys220Arg Uncertain significance Single submitter
- RFC3 p.Cys285Phe Uncertain significance Single submitter
- RFC3 p.Gln126Glu Uncertain significance Single submitter
- RFC3 p.Gln25His Uncertain significance Single submitter
- RFC3 p.Gln306Lys Uncertain significance Single submitter
- RFC3 p.Gln31Arg Uncertain significance Single submitter
- RFC3 p.Glu203Gly Uncertain significance Single submitter
- RFC3 p.Gly101Glu Uncertain significance Single submitter
- RFC3 p.His331Asp Uncertain significance Single submitter
- RFC3 p.Ile108Val Uncertain significance Single submitter
- RFC3 p.Ile189Val Uncertain significance Single submitter
- RFC3 p.Ile286Val Uncertain significance Single submitter
- RFC3 p.Ile329Val Uncertain significance Single submitter
- RFC3 p.Leu16Val Uncertain significance Single submitter
- RFC3 p.Leu211Val Uncertain significance Single submitter
- RFC3 p.Leu278Gln Uncertain significance Single submitter
- RFC3 p.Leu296Phe Uncertain significance Single submitter
- RFC3 p.Leu3Phe Uncertain significance Single submitter
- RFC3 p.Ser169Phe Uncertain significance Single submitter
- RFC3 p.Ser2Arg Uncertain significance Single submitter
- RFC3 p.Ser2Ile Uncertain significance Single submitter
- RFC3 p.Thr141Ser Uncertain significance Single submitter
- RFC3 p.Thr168Ala Uncertain significance Single submitter
- RFC3 p.Thr73Ser Uncertain significance Single submitter
- RFC3 p.Tyr18Cys Uncertain significance Single submitter
- RFC3 p.Tyr343Cys Uncertain significance Single submitter
- RFC3 p.Tyr343His Uncertain significance Single submitter
- RFC3 p.Val137Ala Uncertain significance Single submitter
- RFC3 p.Val311Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All RFC3 variants
Uncertain significance 41
- p.Ala181Val Single submitter ⚠
- p.Ala186Thr Single submitter ⚠
- p.Ala334Val Single submitter ⚠
- p.Arg15Pro Single submitter ⚠
- p.Arg321Cys Single submitter
- p.Arg57Cys Single submitter ⚠
- p.Asn206Thr Single submitter ⚠
- p.Cys220Arg Single submitter ⚠
- p.Cys285Phe Single submitter ⚠
- p.Gln126Glu Single submitter ⚠
- p.Gln25His Single submitter ⚠
- p.Gln306Lys Single submitter ⚠
- p.Gln31Arg Single submitter ⚠
- p.Glu203Gly Single submitter ⚠
- p.Glu273Lys Single submitter ⚠
- p.Gly101Glu Single submitter ⚠
- p.His331Asp Single submitter ⚠
- p.Ile108Val Single submitter ⚠
- p.Ile189Val Single submitter ⚠
- p.Ile262Val Single submitter ⚠
- p.Ile286Val Single submitter ⚠
- p.Ile329Val Single submitter ⚠
- p.Leu16Val Single submitter ⚠
- p.Leu211Val Single submitter ⚠
- p.Leu278Gln Single submitter ⚠
- p.Leu296Phe Single submitter ⚠
- p.Leu3Phe Single submitter ⚠
- p.Ser169Phe Single submitter ⚠
- p.Ser2Arg Single submitter ⚠
- p.Ser2Ile Single submitter ⚠
- p.Thr135Ile Single submitter ⚠
- p.Thr141Ser Single submitter ⚠
- p.Thr168Ala Single submitter ⚠
- p.Thr73Ser Single submitter ⚠
- p.Thr86Ile Single submitter ⚠
- p.Tyr18Cys Single submitter ⚠
- p.Tyr343Cys Single submitter ⚠
- p.Tyr343His Single submitter ⚠
- p.Tyr343Phe Single submitter
- p.Val137Ala Single submitter ⚠
- p.Val311Leu Single submitter ⚠