RGS12 — 256 ClinVar variants

All ClinVar germline RGS12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 231 flagged for review →

17 Likely benign · 239 Uncertain significance

Full RGS12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 231

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 210

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 210

Predictors split 21

The independent predictors disagree with each other — read with care.

All RGS12 variants

Likely benign 17

p.Ala1002Val Single submitter
p.Ala1113Thr Single submitter
p.Ala465Thr Single submitter
p.Arg1399Gln Single submitter
p.Arg913Lys Single submitter
p.Asp321Glu Single submitter
p.His915= Single submitter
p.Ile231Val Single submitter
p.Ile567Val Single submitter
p.Phe102Leu Single submitter
p.Phe982Leu Single submitter
p.Pro1275= Single submitter
p.Pro1397= Single submitter
p.Ser1255Pro Single submitter
p.Ser245Cys Single submitter
p.Val1237Met Single submitter
p.Val99Ile Single submitter

Uncertain significance 239

p.Ala1126Val Single submitter ⚠
p.Ala1254Val Single submitter ⚠
p.Ala1278Pro Single submitter ⚠
p.Ala1309Thr Single submitter ⚠
p.Ala1309Val Single submitter ⚠
p.Ala1408Val Single submitter ⚠
p.Ala1441Thr Single submitter ⚠
p.Ala1444Asp Single submitter ⚠
p.Ala158Val Single submitter ⚠
p.Ala229Val Single submitter ⚠
p.Ala292Thr Single submitter ⚠
p.Ala30Val Single submitter ⚠
p.Ala332Asp Single submitter ⚠
p.Ala332Thr Single submitter ⚠
p.Ala377Val Single submitter ⚠
p.Ala404Ser Single submitter ⚠
p.Ala470Gly Single submitter ⚠
p.Ala489Thr Single submitter ⚠
p.Ala505Ser Single submitter ⚠
p.Ala591Thr Single submitter ⚠
p.Ala597Val Single submitter ⚠
p.Ala606Thr Single submitter ⚠
p.Ala606Val Single submitter ⚠
p.Ala678Thr Single submitter ⚠
p.Ala896Thr Single submitter ⚠
p.Ala922Thr Single submitter ⚠
p.Ala925Val Single submitter ⚠
p.Ala949Thr Single submitter ⚠
p.Arg1028His Single submitter ⚠
p.Arg1032His Single submitter ⚠
p.Arg10Cys Single submitter ⚠
p.Arg10His Single submitter ⚠
p.Arg1163Trp Single submitter ⚠
p.Arg1221His Single submitter ⚠
p.Arg1251Gln Single submitter ⚠
p.Arg1251Gly Single submitter ⚠
p.Arg136Gln Single submitter ⚠
p.Arg178Leu Single submitter ⚠
p.Arg19Lys Single submitter ⚠
p.Arg21Trp Single submitter ⚠
p.Arg256Cys Single submitter
p.Arg260Trp Single submitter ⚠
p.Arg261Cys Single submitter ⚠
p.Arg261His Single submitter ⚠
p.Arg27Gln Single submitter ⚠
p.Arg309Trp Single submitter ⚠
p.Arg357Leu Single submitter ⚠
p.Arg357Trp Single submitter ⚠
p.Arg391Gln Single submitter ⚠
p.Arg403Cys Single submitter ⚠
p.Arg403His Single submitter ⚠
p.Arg437Trp Single submitter
p.Arg494Thr Single submitter ⚠
p.Arg544Trp Single submitter ⚠
p.Arg643Cys Single submitter ⚠
p.Arg647Gln Single submitter ⚠
p.Arg647Trp Single submitter ⚠
p.Arg702Trp Single submitter ⚠
p.Arg767Gln Single submitter ⚠
p.Arg796Cys Single submitter ⚠
p.Arg796His Single submitter ⚠
p.Arg893Trp Single submitter ⚠
p.Arg902Leu Single submitter ⚠
p.Arg931Cys Single submitter ⚠
p.Arg994Gln Single submitter ⚠
p.Asn1133His Single submitter ⚠
p.Asn148Tyr Single submitter ⚠
p.Asn752Ser Single submitter ⚠
p.Asn926Ser Single submitter ⚠
p.Asp1105Val Single submitter ⚠
p.Asp1213Tyr Single submitter ⚠
p.Asp1269Asn Single submitter ⚠
p.Asp205Gly Single submitter ⚠
p.Asp322Asn Single submitter ⚠
p.Asp345Glu Single submitter ⚠
p.Asp407Asn Single submitter ⚠
p.Asp559Tyr Single submitter ⚠
p.Asp562Asn Single submitter ⚠
p.Asp679Asn Single submitter ⚠
p.Asp785Asn Single submitter ⚠
p.Asp888Glu Single submitter ⚠
p.Cys372Ser Single submitter ⚠
p.Cys548Arg Single submitter ⚠
p.Cys974Tyr Single submitter ⚠
p.Gln1097His Single submitter ⚠
p.Gln1265Lys Single submitter ⚠
p.Gln1310Lys Single submitter ⚠
p.Gln1315Glu Single submitter ⚠
p.Glu103Gln Single submitter ⚠
p.Glu109Asp Single submitter ⚠
p.Glu115Asp Single submitter ⚠
p.Glu1259Lys Single submitter ⚠
p.Glu1339Lys Single submitter ⚠
p.Glu197Ala Single submitter ⚠
p.Glu297Lys Single submitter ⚠
p.Glu330Gly Single submitter ⚠
p.Glu481Lys Single submitter ⚠
p.Glu740Gln Single submitter ⚠
p.Glu749Val Single submitter ⚠
p.Glu993Gln Single submitter ⚠
p.Gly1008Ser Single submitter ⚠
p.Gly1009Glu Single submitter ⚠
p.Gly100Ser Single submitter ⚠
p.Gly1138Val Single submitter ⚠
p.Gly118Val Single submitter ⚠
p.Gly1328Asp Single submitter ⚠
p.Gly1398Arg Single submitter ⚠
p.Gly1402Val Single submitter ⚠
p.Gly257Cys Single submitter ⚠
p.Gly323Arg Single submitter ⚠
p.Gly425Ser Single submitter ⚠
p.Gly451Ser Single submitter ⚠
p.Gly453Arg Single submitter ⚠
p.Gly464Arg Single submitter ⚠
p.Gly469Ser Single submitter ⚠
p.Gly528Ser Single submitter ⚠
p.Gly677Val Single submitter ⚠
p.Gly916Glu Single submitter ⚠
p.Gly999Trp Single submitter ⚠
p.His1376Asp Single submitter ⚠
p.His204Arg Single submitter ⚠
p.His204Leu Single submitter ⚠
p.His616Leu Single submitter ⚠
p.Ile1171Val Single submitter ⚠
p.Ile1174Thr Single submitter ⚠
p.Ile1329Phe Single submitter ⚠
p.Ile203Phe Single submitter ⚠
p.Ile84Phe Single submitter ⚠
p.Leu1006Val Single submitter ⚠
p.Leu1085Pro Single submitter ⚠
p.Leu1231Arg Single submitter ⚠
p.Leu235Val Single submitter
p.Leu380Phe Single submitter ⚠
p.Leu406Val Single submitter ⚠
p.Leu44Phe Single submitter ⚠
p.Leu498Pro Single submitter ⚠
p.Leu58Pro Single submitter ⚠
p.Leu665Val Single submitter ⚠
p.Leu923Pro Single submitter ⚠
p.Lys1051Glu Single submitter ⚠
p.Lys1178Ile Single submitter ⚠
p.Lys117Glu Single submitter ⚠
p.Lys500Glu Single submitter ⚠
p.Lys82Glu Single submitter ⚠
p.Lys911Gln Single submitter ⚠
p.Met149Lys Single submitter ⚠
p.Met317Ile Single submitter ⚠
p.Met317Val Single submitter ⚠
p.Phe631Ser Single submitter ⚠
p.Pro1084Thr Single submitter ⚠
p.Pro1232Arg Single submitter ⚠
p.Pro1271Leu Single submitter ⚠
p.Pro1275Arg Single submitter ⚠
p.Pro1275Leu Single submitter ⚠
p.Pro1281Leu Single submitter ⚠
p.Pro1282Ala Single submitter ⚠
p.Pro1282Ser Single submitter ⚠
p.Pro1290Ala Single submitter ⚠
p.Pro1290His Single submitter ⚠
p.Pro1290Ser Single submitter ⚠
p.Pro1290Thr Single submitter ⚠
p.Pro1305Leu Single submitter ⚠
p.Pro1351Leu Single submitter ⚠
p.Pro1371Ser Single submitter ⚠
p.Pro1382Leu Single submitter ⚠
p.Pro1410Leu Single submitter ⚠
p.Pro1431Leu Single submitter ⚠
p.Pro15Leu Single submitter ⚠
p.Pro306Leu Single submitter
p.Pro452Thr Single submitter ⚠
p.Pro478Leu Single submitter ⚠
p.Pro512Ala Single submitter ⚠
p.Pro521His Single submitter ⚠
p.Pro521Thr Single submitter ⚠
p.Pro593Leu Single submitter ⚠
p.Pro593Ser Single submitter ⚠
p.Pro598Arg Single submitter ⚠
p.Pro969Leu Single submitter ⚠
p.Ser107Cys Single submitter
p.Ser1092Leu Single submitter
p.Ser1135Leu Single submitter ⚠
p.Ser1242Arg Single submitter ⚠
p.Ser1245Thr Single submitter ⚠
p.Ser1253Thr Single submitter ⚠
p.Ser1272Tyr Single submitter ⚠
p.Ser1307Thr Single submitter ⚠
p.Ser1440Gly Single submitter ⚠
p.Ser174Leu Single submitter ⚠
p.Ser185Gly Single submitter ⚠
p.Ser22Asn Single submitter ⚠
p.Ser249Phe Single submitter ⚠
p.Ser419Ile Single submitter ⚠
p.Ser447Leu Single submitter ⚠
p.Ser649Thr Single submitter ⚠
p.Ser688Asn Single submitter ⚠
p.Ser715Thr Single submitter
p.Ser730Ala Single submitter ⚠
p.Ser899Leu Single submitter ⚠
p.Ser934Leu Single submitter ⚠
p.Ser947Leu Single submitter ⚠
p.Thr1057Met Single submitter ⚠
p.Thr1137Met Single submitter ⚠
p.Thr1233Ala Single submitter ⚠
p.Thr1287Arg Single submitter ⚠
p.Thr1287Met Single submitter ⚠
p.Thr1288Ser Single submitter ⚠
p.Thr1331Met Single submitter ⚠
p.Thr1341Asn Single submitter ⚠
p.Thr1341Ile Single submitter ⚠
p.Thr319Met Single submitter ⚠
p.Thr364Met Single submitter
p.Thr906Ile Single submitter ⚠
p.Trp119Leu Single submitter ⚠
p.Trp1261Ser Single submitter ⚠
p.Trp468Ser Single submitter ⚠
p.Tyr114Cys Single submitter ⚠
p.Val1040Phe Single submitter ⚠
p.Val1056Ile Single submitter ⚠
p.Val1063Met Single submitter ⚠
p.Val1064Leu Single submitter ⚠
p.Val1127Ile Single submitter ⚠
p.Val1306Gly Single submitter ⚠
p.Val1306Ile Single submitter ⚠
p.Val1337Met Single submitter ⚠
p.Val1389Ala Single submitter ⚠
p.Val1447Ile Single submitter ⚠
p.Val202Ala Single submitter ⚠
p.Val202Ile Single submitter ⚠
p.Val304Met Single submitter ⚠
p.Val382Ile Single submitter ⚠
p.Val382Phe Single submitter ⚠
p.Val510Met Single submitter ⚠
p.Val527Met Single submitter ⚠
p.Val542Met Single submitter ⚠
p.Val684Ile Single submitter ⚠
p.Val698Leu Single submitter ⚠
p.Val698Met Single submitter ⚠
p.Val724Ile Single submitter ⚠
p.Val975Met Single submitter ⚠