RGS16 — 27 ClinVar variants
All ClinVar germline RGS16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Likely benign · 26 Uncertain significance
Full RGS16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RGS16 p.Ala114Thr Uncertain significance Single submitter
- RGS16 p.Ala182Thr Uncertain significance Single submitter
- RGS16 p.Ala7Thr Uncertain significance Single submitter
- RGS16 p.Arg160Cys Uncertain significance Single submitter
- RGS16 p.Arg178Gly Uncertain significance Single submitter
- RGS16 p.Asp133Gly Uncertain significance Single submitter
- RGS16 p.Glu43Lys Uncertain significance Single submitter
- RGS16 p.Glu89Asp Uncertain significance Single submitter
- RGS16 p.Gly33Val Uncertain significance Single submitter
- RGS16 p.Gly45Ser Uncertain significance Single submitter
- RGS16 p.His115Asn Uncertain significance Single submitter
- RGS16 p.His201Tyr Uncertain significance Single submitter
- RGS16 p.Ile132Val Uncertain significance Single submitter
- RGS16 p.Leu180Pro Uncertain significance Single submitter
- RGS16 p.Lys109Arg Uncertain significance Single submitter
- RGS16 p.Phe42Leu Uncertain significance Single submitter
- RGS16 p.Phe87Val Uncertain significance Single submitter
- RGS16 p.Ser30Leu Uncertain significance Single submitter
- RGS16 p.Thr11Ile Uncertain significance Single submitter
- RGS16 p.Thr11Ser Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All RGS16 variants
Likely benign 1
- p.Ser49Gly Single submitter
Uncertain significance 26
- p.Ala114Thr Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala184Val Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Arg160Cys Single submitter ⚠
- p.Arg170His Single submitter
- p.Arg178Gly Single submitter ⚠
- p.Arg178Trp Single submitter ⚠
- p.Asp133Gly Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Glu51Gly Single submitter ⚠
- p.Glu89Asp Single submitter ⚠
- p.Gly33Val Single submitter ⚠
- p.Gly45Ser Single submitter ⚠
- p.His115Asn Single submitter ⚠
- p.His201Tyr Single submitter ⚠
- p.Ile132Val Single submitter ⚠
- p.Leu180Pro Single submitter ⚠
- p.Lys109Arg Single submitter ⚠
- p.Phe42Leu Single submitter ⚠
- p.Phe87Val Single submitter ⚠
- p.Ser30Leu Single submitter ⚠
- p.Thr11Ile Single submitter ⚠
- p.Thr11Ser Single submitter ⚠
- p.Thr140Met Single submitter ⚠
- p.Thr85Arg Single submitter ⚠