RGS19 — 33 ClinVar variants
All ClinVar germline RGS19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 32 Uncertain significance
Full RGS19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RGS19 p.Ala106Thr Uncertain significance Single submitter
- RGS19 p.Ala204Thr Uncertain significance Single submitter
- RGS19 p.Ala32Val Uncertain significance Single submitter
- RGS19 p.Arg109Gln Uncertain significance Single submitter
- RGS19 p.Arg162Gln Uncertain significance Single submitter
- RGS19 p.Arg55Gln Uncertain significance Single submitter
- RGS19 p.Arg56Gln Uncertain significance Single submitter
- RGS19 p.Arg63Gln Uncertain significance Single submitter
- RGS19 p.Gln10Lys Uncertain significance Single submitter
- RGS19 p.Gln170Glu Uncertain significance Single submitter
- RGS19 p.Glu16Ala Uncertain significance Single submitter
- RGS19 p.Glu216Gln Uncertain significance Single submitter
- RGS19 p.Glu216Lys Uncertain significance Single submitter
- RGS19 p.Leu41Pro Uncertain significance Single submitter
- RGS19 p.Lys167Glu Uncertain significance Single submitter
- RGS19 p.Phe177Val Uncertain significance Single submitter
- RGS19 p.Pro172Leu Uncertain significance Single submitter
- RGS19 p.Ser211Leu Uncertain significance Single submitter
- RGS19 p.Ser86Gly Uncertain significance Single submitter
- RGS19 p.Val103Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- RGS19 p.Arg140Lys Uncertain significance Single submitter
- RGS19 p.Arg160Cys Uncertain significance Single submitter
- RGS19 p.Asn166Lys Uncertain significance Single submitter
- RGS19 p.Asp178Asn Uncertain significance Single submitter
- RGS19 p.Glu137Lys Uncertain significance Single submitter
- RGS19 p.Glu144Lys Uncertain significance Single submitter
- RGS19 p.Met117Ile Uncertain significance Single submitter
- RGS19 p.Thr186Ala Uncertain significance Single submitter
- RGS19 p.Thr186Met Uncertain significance Single submitter
All RGS19 variants
Likely benign 1
- p.Arg19Gln Single submitter
Uncertain significance 32
- c.227+1_227+12delinsTAT Single submitter
- c.227+1del Single submitter
- p.Ala106Thr Single submitter ⚠
- p.Ala204Thr Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Arg109Gln Single submitter ⚠
- p.Arg140Lys Single submitter ⚠
- p.Arg160Cys Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg56Gln Single submitter ⚠
- p.Arg63Gln Single submitter ⚠
- p.Asn166Lys Single submitter ⚠
- p.Asp178Asn Single submitter ⚠
- p.Gln10Lys Single submitter ⚠
- p.Gln170Glu Single submitter ⚠
- p.Glu124Gln Single submitter
- p.Glu137Lys Single submitter ⚠
- p.Glu144Lys Single submitter ⚠
- p.Glu16Ala Single submitter ⚠
- p.Glu216Gln Single submitter ⚠
- p.Glu216Lys Single submitter ⚠
- p.Leu41Pro Single submitter ⚠
- p.Lys167Glu Single submitter ⚠
- p.Met117Ile Single submitter ⚠
- p.Phe177Val Single submitter ⚠
- p.Pro172Leu Single submitter ⚠
- p.Ser211Leu Single submitter ⚠
- p.Ser86Gly Single submitter ⚠
- p.Thr186Ala Single submitter ⚠
- p.Thr186Met Single submitter ⚠
- p.Val103Met Single submitter ⚠