RGS4 — 37 ClinVar variants
All ClinVar germline RGS4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely benign · 36 Uncertain significance
Full RGS4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RGS4 p.Ala10Ser Uncertain significance Single submitter
- RGS4 p.Ala74Thr Uncertain significance Single submitter
- RGS4 p.Ala78Thr Uncertain significance Single submitter
- RGS4 p.Arg134Trp Uncertain significance Single submitter
- RGS4 p.Arg166His Uncertain significance Single submitter
- RGS4 p.Cys132Tyr Uncertain significance Single submitter
- RGS4 p.Cys183Tyr Uncertain significance Single submitter
- RGS4 p.Cys197Gly Uncertain significance Single submitter
- RGS4 p.Glu136Ala Uncertain significance Single submitter
- RGS4 p.Glu136Gln Uncertain significance Single submitter
- RGS4 p.Glu151Lys Uncertain significance Single submitter
- RGS4 p.Glu54Asp Uncertain significance Single submitter
- RGS4 p.Glu70Ala Uncertain significance Single submitter
- RGS4 p.Leu175Ile Uncertain significance Single submitter
- RGS4 p.Leu23Ile Uncertain significance Single submitter
- RGS4 p.Lys113Arg Uncertain significance Single submitter
- RGS4 p.Lys187Asn Uncertain significance Single submitter
- RGS4 p.Lys192Glu Uncertain significance Single submitter
- RGS4 p.Lys57Arg Uncertain significance Single submitter
- RGS4 p.Pro104Leu Uncertain significance Single submitter
- RGS4 p.Pro180Arg Uncertain significance Single submitter
- RGS4 p.Pro180Leu Uncertain significance Single submitter
- RGS4 p.Ser30Phe Uncertain significance Single submitter
- RGS4 p.Thr147Asn Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RGS4 variants
Likely benign 1
- p.Gly15Glu Single submitter
Uncertain significance 36
- c.-38T>C Single submitter
- c.-47C>T Single submitter
- c.-52C>G Single submitter
- c.-62G>T Single submitter
- p.Ala10Ser Single submitter ⚠
- p.Ala21Ser Single submitter
- p.Ala74Thr Single submitter ⚠
- p.Ala78Thr Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Arg43Leu Single submitter
- p.Arg43Ser Single submitter
- p.Cys132Tyr Single submitter ⚠
- p.Cys183Tyr Single submitter ⚠
- p.Cys197Gly Single submitter ⚠
- p.Glu136Ala Single submitter ⚠
- p.Glu136Gln Single submitter ⚠
- p.Glu151Lys Single submitter ⚠
- p.Glu54Asp Single submitter ⚠
- p.Glu70Ala Single submitter ⚠
- p.Glu97Gly Single submitter ⚠
- p.Gly22Arg Single submitter
- p.Gly42Cys Single submitter
- p.Leu13Phe Single submitter ⚠
- p.Leu175Ile Single submitter ⚠
- p.Leu23Ile Single submitter ⚠
- p.Lys113Arg Single submitter ⚠
- p.Lys187Asn Single submitter ⚠
- p.Lys192Glu Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Pro104Leu Single submitter ⚠
- p.Pro180Arg Single submitter ⚠
- p.Pro180Leu Single submitter ⚠
- p.Ser30Phe Single submitter ⚠
- p.Thr147Asn Single submitter ⚠
- p.Thr52Lys Single submitter