RGS8 — 16 ClinVar variants
All ClinVar germline RGS8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
1 Benign · 15 Uncertain significance
Full RGS8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RGS8 p.Ala50Val Uncertain significance Single submitter
- RGS8 p.Arg119Gln Uncertain significance Single submitter
- RGS8 p.Asn10Lys Uncertain significance Single submitter
- RGS8 p.Asn134Lys Uncertain significance Single submitter
- RGS8 p.Glu49Asp Uncertain significance Single submitter
- RGS8 p.Glu84Asp Uncertain significance Single submitter
- RGS8 p.Lys100Glu Uncertain significance Single submitter
- RGS8 p.Met167Ile Uncertain significance Single submitter
- RGS8 p.Phe162Leu Uncertain significance Single submitter
- RGS8 p.Ser21Cys Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RGS8 variants
Benign 1
- p.Thr95Ile Single submitter
Uncertain significance 15
- c.-123A>G Single submitter
- c.-164G>A Single submitter
- p.Ala50Val Single submitter ⚠
- p.Ala88Thr Single submitter
- p.Arg119Gln Single submitter ⚠
- p.Arg40Cys Single submitter ⚠
- p.Asn10Lys Single submitter ⚠
- p.Asn134Lys Single submitter ⚠
- p.Glu49Asp Single submitter ⚠
- p.Glu84Asp Single submitter ⚠
- p.Lys100Glu Single submitter ⚠
- p.Met167Ile Single submitter ⚠
- p.Phe162Leu Single submitter ⚠
- p.Phe92Leu Single submitter ⚠
- p.Ser21Cys Single submitter ⚠