RHOB — 10 ClinVar variants
All ClinVar germline RHOB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
1 Conflicting · 9 Uncertain significance
Full RHOB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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RHOB p.Ser73Phe
Conflicting
Single submitter
RHOB-related disorder
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RHOB p.Ala116Thr Uncertain significance Single submitter
- RHOB p.Ile151Ser Uncertain significance Single submitter
- RHOB p.Ile190Met Uncertain significance Single submitter
- RHOB p.Ile23Thr Uncertain significance Single submitter
- RHOB p.Met82Ile Uncertain significance Single submitter
- RHOB p.Pro101Leu Uncertain significance Single submitter
- RHOB p.Thr141Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RHOB variants
Conflicting classifications of pathogenicity 1
- p.Ser73Phe Single submitter RHOB-related disorder ⚠
Uncertain significance 9
- p.Ala116Thr Single submitter ⚠
- p.Gln52Glu Single submitter ⚠
- p.Gly50Ser Single submitter ⚠
- p.Ile151Ser Single submitter ⚠
- p.Ile190Met Single submitter ⚠
- p.Ile23Thr Single submitter ⚠
- p.Met82Ile Single submitter ⚠
- p.Pro101Leu Single submitter ⚠
- p.Thr141Ala Single submitter ⚠