RHOC — 16 ClinVar variants
All ClinVar germline RHOC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
16 Uncertain significance
Full RHOC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RHOC p.Ala148Val Uncertain significance Single submitter
- RHOC p.Arg150Pro Uncertain significance Single submitter
- RHOC p.Arg182His Uncertain significance Single submitter
- RHOC p.Ile113Met Uncertain significance Single submitter
- RHOC p.Ile192Asn Uncertain significance Single submitter
- RHOC p.Met173Val Uncertain significance Single submitter
- RHOC p.Phe171Ser Uncertain significance Single submitter
- RHOC p.Val11Ile Uncertain significance Single submitter
- RHOC p.Val11Phe Uncertain significance Single submitter
- RHOC p.Val139Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RHOC variants
Uncertain significance 16
- p.Ala148Val Single submitter ⚠
- p.Arg140Trp Single submitter
- p.Arg150Pro Single submitter ⚠
- p.Arg182Cys Single submitter
- p.Arg182His Single submitter ⚠
- p.Gln180His Single submitter ⚠
- p.Ile113Met Single submitter ⚠
- p.Ile192Asn Single submitter ⚠
- p.Ile23Met Single submitter ⚠
- p.Leu157Phe Single submitter
- p.Met173Val Single submitter ⚠
- p.Met82Leu Single submitter
- p.Phe171Ser Single submitter ⚠
- p.Val11Ile Single submitter ⚠
- p.Val11Phe Single submitter ⚠
- p.Val139Ile Single submitter ⚠