RHOH — 88 ClinVar variants
All ClinVar germline RHOH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Benign/Likely benign · 47 Likely benign · 39 Uncertain significance
Full RHOH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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RHOH p.Arg157Gln
Uncertain significance
Multiple submitters
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Gly61Ser
Uncertain significance
Multiple submitters
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Ser104Gly
Uncertain significance
Multiple submitters
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Ala166Thr
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Ala32Val
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Ala64Ser
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Ala76Pro
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Arg168Gln
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Arg177Gln
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Asn132Ser
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Asn172Ser
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Gln141Arg
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.His88Arg
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Ile68Val
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Leu139Val
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Lys146Gln
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
- RHOH p.Lys146Thr Uncertain significance Single submitter
-
RHOH p.Lys34Arg
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
- RHOH p.Met123Leu Uncertain significance Single submitter
-
RHOH p.Met134Thr
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
- RHOH p.Met47Leu Uncertain significance Single submitter
-
RHOH p.Met81Val
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
- RHOH p.Pro30Arg Uncertain significance Single submitter
-
RHOH p.Ser104Asn
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Ser155Asn
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
- RHOH p.Tyr73Cys Uncertain significance Single submitter
-
RHOH p.Val111Leu
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Val131Ile
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
Predictors split 8
The independent predictors disagree with each other — read with care.
-
RHOH p.Arg180Trp
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Arg69Trp
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Asp63Val
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Gln75Pro
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Leu56Phe
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Pro30Leu
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Pro30Ser
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
-
RHOH p.Val10Ala
Uncertain significance
Single submitter
T-cell immunodeficiency with epidermodysplasia verruciformis
All RHOH variants
Benign/Likely benign 2
Likely benign 47
- p.Ala14= Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Ala166= Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Asp77= Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Cys165= Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Leu9= Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Tyr73= Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Val171Ile Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis
- c.-1G>A Single submitter
- p.Ala133= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Ala60= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Ala64= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Arg157= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Arg179= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Arg69= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Asn186= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Asn96= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Asp44= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Asp58= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Asp63= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Cys130= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Cys7= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Gln120= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Gly11= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Gly136= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Gly147= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Gly16= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Gly42= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Gly55= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Ile190= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Leu112= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Leu139= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Leu149= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Leu182= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Leu94= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Lys6= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Pro30= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Pro35= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Pro70= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Ser26= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Ser53= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Ser84= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Thr25= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Tyr33= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Tyr38= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Val113= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Val15= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Val43= Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
Uncertain significance 39
- p.Arg157Gln Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Gly61Ser Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Ser104Gly Multiple submitters T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Ala166Thr Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Ala32Val Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Ala64Ser Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Ala76Pro Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Arg168Gln Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Arg177Gln Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Arg180Trp Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Arg181del Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Arg69Trp Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Asn132Ser Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Asn172Ser Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Asp63Val Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Gln141Arg Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Gln160Ter Single submitter epidermodysplasia verruciformis, susceptibility to, 4
- p.Gln75Pro Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.His88Arg Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Ile68Val Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Leu139Val Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Leu56Phe Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Lys146Gln Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Lys146Thr Single submitter ⚠
- p.Lys34Arg Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Met123Leu Single submitter ⚠
- p.Met134Thr Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Met47Leu Single submitter ⚠
- p.Met81Val Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Pro110fs Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis
- p.Pro30Arg Single submitter ⚠
- p.Pro30Leu Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Pro30Ser Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Ser104Asn Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Ser155Asn Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Tyr73Cys Single submitter ⚠
- p.Val10Ala Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Val111Leu Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠
- p.Val131Ile Single submitter T-cell immunodeficiency with epidermodysplasia verruciformis ⚠