Sugi Variant

Sugi Variant/RIN2

RIN2 — 667 ClinVar variants

All ClinVar germline RIN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 288 flagged for review →

11 Pathogenic · 6 Likely pathogenic · 18 Conflicting · 43 Benign · 18 Benign/Likely benign · 257 Likely benign · 314 Uncertain significance

Full RIN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 288

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 12

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 226

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 226

Predictors split 50

The independent predictors disagree with each other — read with care.

All RIN2 variants

Pathogenic 11

Likely pathogenic 6

Conflicting classifications of pathogenicity 18

Benign 43

Benign/Likely benign 18

Likely benign 257

Uncertain significance 314

Showing the top 300 by review status; the full set is in the sitemap.