RIOX2 — 90 ClinVar variants
All ClinVar germline RIOX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
4 Likely benign · 86 Uncertain significance
Full RIOX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RIOX2 p.Ala304Asp Uncertain significance Single submitter
- RIOX2 p.Ala304Ser Uncertain significance Single submitter
- RIOX2 p.Arg104Gln Uncertain significance Single submitter
- RIOX2 p.Arg216Ser Uncertain significance Single submitter
- RIOX2 p.Arg307Gln Uncertain significance Single submitter
- RIOX2 p.Arg418Cys Uncertain significance Single submitter
- RIOX2 p.Asn101Asp Uncertain significance Single submitter
- RIOX2 p.Asn262Tyr Uncertain significance Single submitter
- RIOX2 p.Asp329Asn Uncertain significance Single submitter
- RIOX2 p.Asp69His Uncertain significance Single submitter
- RIOX2 p.Gln136Lys Uncertain significance Single submitter
- RIOX2 p.Glu208Asp Uncertain significance Single submitter
- RIOX2 p.Glu402Asp Uncertain significance Single submitter
- RIOX2 p.Gly117Ala Uncertain significance Single submitter
- RIOX2 p.Gly163Ser Uncertain significance Single submitter
- RIOX2 p.Gly229Ser Uncertain significance Single submitter
- RIOX2 p.Gly237Glu Uncertain significance Single submitter
- RIOX2 p.Gly289Asp Uncertain significance Single submitter
- RIOX2 p.Ile150Thr Uncertain significance Single submitter
- RIOX2 p.Ile462Ser Uncertain significance Single submitter
- RIOX2 p.Leu147Ile Uncertain significance Single submitter
- RIOX2 p.Leu454Val Uncertain significance Single submitter
- RIOX2 p.Leu65Phe Uncertain significance Single submitter
- RIOX2 p.Lys281Arg Uncertain significance Single submitter
- RIOX2 p.Lys323Glu Uncertain significance Single submitter
- RIOX2 p.Lys332Arg Uncertain significance Single submitter
- RIOX2 p.Lys356Arg Uncertain significance Single submitter
- RIOX2 p.Met22Ile Uncertain significance Single submitter
- RIOX2 p.Met330Val Uncertain significance Single submitter
- RIOX2 p.Met94Val Uncertain significance Single submitter
- RIOX2 p.Phe414Val Uncertain significance Single submitter
- RIOX2 p.Pro16Leu Uncertain significance Single submitter
- RIOX2 p.Pro341Ser Uncertain significance Single submitter
- RIOX2 p.Pro341Thr Uncertain significance Single submitter
- RIOX2 p.Pro358Arg Uncertain significance Single submitter
- RIOX2 p.Ser164Leu Uncertain significance Single submitter
- RIOX2 p.Ser251Phe Uncertain significance Single submitter
- RIOX2 p.Ser31Thr Uncertain significance Single submitter
- RIOX2 p.Ser343Cys Uncertain significance Single submitter
- RIOX2 p.Ser343Phe Uncertain significance Single submitter
- RIOX2 p.Ser455Cys Uncertain significance Single submitter
- RIOX2 p.Thr352Lys Uncertain significance Single submitter
- RIOX2 p.Trp431Ser Uncertain significance Single submitter
- RIOX2 p.Tyr199Cys Uncertain significance Single submitter
- RIOX2 p.Val211Met Uncertain significance Single submitter
- RIOX2 p.Val276Leu Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- RIOX2 p.Ala133Thr Uncertain significance Single submitter
- RIOX2 p.Ala171Thr Uncertain significance Single submitter
- RIOX2 p.Ala246Val Uncertain significance Single submitter
- RIOX2 p.Ala249Val Uncertain significance Single submitter
- RIOX2 p.Arg104Trp Uncertain significance Single submitter
- RIOX2 p.Arg197Cys Uncertain significance Single submitter
- RIOX2 p.Arg287Trp Uncertain significance Single submitter
- RIOX2 p.Arg292Trp Uncertain significance Single submitter
- RIOX2 p.Arg307Leu Uncertain significance Single submitter
- RIOX2 p.Arg313Thr Uncertain significance Single submitter
- RIOX2 p.Arg318Gln Uncertain significance Single submitter
- RIOX2 p.Arg318Trp Uncertain significance Single submitter
- RIOX2 p.Arg68Gly Uncertain significance Single submitter
- RIOX2 p.Arg92Trp Uncertain significance Single submitter
- RIOX2 p.Asp270Asn Uncertain significance Single submitter
- RIOX2 p.Cys90Arg Uncertain significance Single submitter
- RIOX2 p.Glu152Gly Uncertain significance Single submitter
- RIOX2 p.Glu193Asp Uncertain significance Single submitter
- RIOX2 p.Glu214Lys Uncertain significance Single submitter
- RIOX2 p.Gly218Val Uncertain significance Single submitter
- RIOX2 p.Gly289Cys Uncertain significance Single submitter
- RIOX2 p.Gly289Ser Uncertain significance Single submitter
- RIOX2 p.His423Arg Uncertain significance Single submitter
- RIOX2 p.Ile272Thr Uncertain significance Single submitter
- RIOX2 p.Leu294Pro Uncertain significance Single submitter
- RIOX2 p.Leu397Val Uncertain significance Single submitter
- RIOX2 p.Leu417Arg Uncertain significance Single submitter
- RIOX2 p.Leu417Phe Uncertain significance Single submitter
- RIOX2 p.Lys153Met Uncertain significance Single submitter
- RIOX2 p.Met405Ile Uncertain significance Single submitter
- RIOX2 p.Met94Arg Uncertain significance Single submitter
- RIOX2 p.Phe143Leu Uncertain significance Single submitter
- RIOX2 p.Pro177Leu Uncertain significance Single submitter
- RIOX2 p.Pro378Leu Uncertain significance Single submitter
- RIOX2 p.Pro63Ala Uncertain significance Single submitter
- RIOX2 p.Ser273Leu Uncertain significance Single submitter
- RIOX2 p.Thr314Ile Uncertain significance Single submitter
- RIOX2 p.Tyr77Cys Uncertain significance Single submitter
- RIOX2 p.Tyr96Cys Uncertain significance Single submitter
- RIOX2 p.Val254Met Uncertain significance Single submitter
All RIOX2 variants
Likely benign 4
- p.Ala344Val Single submitter
- p.Ile335Val Single submitter
- p.Leu24Val Single submitter
- p.Thr8Ala Single submitter
Uncertain significance 86
- p.Ala133Thr Single submitter ⚠
- p.Ala171Thr Single submitter ⚠
- p.Ala246Val Single submitter ⚠
- p.Ala249Val Single submitter ⚠
- p.Ala304Asp Single submitter ⚠
- p.Ala304Ser Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg104Trp Single submitter ⚠
- p.Arg197Cys Single submitter ⚠
- p.Arg216Ser Single submitter ⚠
- p.Arg287Trp Single submitter ⚠
- p.Arg292Trp Single submitter ⚠
- p.Arg307Gln Single submitter ⚠
- p.Arg307Leu Single submitter ⚠
- p.Arg313Thr Single submitter ⚠
- p.Arg318Gln Single submitter ⚠
- p.Arg318Trp Single submitter ⚠
- p.Arg418Cys Single submitter ⚠
- p.Arg68Gly Single submitter ⚠
- p.Arg92Trp Single submitter ⚠
- p.Asn101Asp Single submitter ⚠
- p.Asn262Tyr Single submitter ⚠
- p.Asp270Asn Single submitter ⚠
- p.Asp329Asn Single submitter ⚠
- p.Asp69His Single submitter ⚠
- p.Cys90Arg Single submitter ⚠
- p.Gln136Lys Single submitter ⚠
- p.Glu152Gly Single submitter ⚠
- p.Glu193Asp Single submitter ⚠
- p.Glu208Asp Single submitter ⚠
- p.Glu214Lys Single submitter ⚠
- p.Glu402Asp Single submitter ⚠
- p.Gly117Ala Single submitter ⚠
- p.Gly163Ser Single submitter ⚠
- p.Gly218Val Single submitter ⚠
- p.Gly229Ser Single submitter ⚠
- p.Gly237Glu Single submitter ⚠
- p.Gly289Asp Single submitter ⚠
- p.Gly289Cys Single submitter ⚠
- p.Gly289Ser Single submitter ⚠
- p.His423Arg Single submitter ⚠
- p.Ile150Thr Single submitter ⚠
- p.Ile272Thr Single submitter ⚠
- p.Ile462Ser Single submitter ⚠
- p.Leu147Ile Single submitter ⚠
- p.Leu294Pro Single submitter ⚠
- p.Leu397Val Single submitter ⚠
- p.Leu417Arg Single submitter ⚠
- p.Leu417Phe Single submitter ⚠
- p.Leu454Val Single submitter ⚠
- p.Leu65Phe Single submitter ⚠
- p.Lys153Met Single submitter ⚠
- p.Lys281Arg Single submitter ⚠
- p.Lys323Glu Single submitter ⚠
- p.Lys332Arg Single submitter ⚠
- p.Lys356Arg Single submitter ⚠
- p.Met22Ile Single submitter ⚠
- p.Met330Val Single submitter ⚠
- p.Met405Ile Single submitter ⚠
- p.Met94Arg Single submitter ⚠
- p.Met94Val Single submitter ⚠
- p.Phe143Leu Single submitter ⚠
- p.Phe414Val Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro177Leu Single submitter ⚠
- p.Pro341Ser Single submitter ⚠
- p.Pro341Thr Single submitter ⚠
- p.Pro358Arg Single submitter ⚠
- p.Pro378Leu Single submitter ⚠
- p.Pro63Ala Single submitter ⚠
- p.Ser164Leu Single submitter ⚠
- p.Ser251Phe Single submitter ⚠
- p.Ser273Leu Single submitter ⚠
- p.Ser31Thr Single submitter ⚠
- p.Ser343Cys Single submitter ⚠
- p.Ser343Phe Single submitter ⚠
- p.Ser455Cys Single submitter ⚠
- p.Thr314Ile Single submitter ⚠
- p.Thr352Lys Single submitter ⚠
- p.Trp431Ser Single submitter ⚠
- p.Tyr199Cys Single submitter ⚠
- p.Tyr77Cys Single submitter ⚠
- p.Tyr96Cys Single submitter ⚠
- p.Val211Met Single submitter ⚠
- p.Val254Met Single submitter ⚠
- p.Val276Leu Single submitter ⚠