Sugi Variant

Sugi Variant/RIPK1

RIPK1 — 580 ClinVar variants

All ClinVar germline RIPK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 299 flagged for review →

17 Pathogenic · 1 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 21 Conflicting · 6 Benign · 7 Benign/Likely benign · 190 Likely benign · 328 Uncertain significance

Full RIPK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 299

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 18

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 246

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 246

Predictors split 34

The independent predictors disagree with each other — read with care.

All RIPK1 variants

Pathogenic 17

Pathogenic/Likely pathogenic 1

  • p.Met318fs No assertion criteria IL10-related early-onset inflammatory bowel disease

Likely pathogenic 10

Conflicting classifications of pathogenicity 21

Benign 6

Benign/Likely benign 7

Likely benign 190

Uncertain significance 328

Showing the top 300 by review status; the full set is in the sitemap.