RIPK3 — 71 ClinVar variants
All ClinVar germline RIPK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
1 Conflicting · 11 Likely benign · 59 Uncertain significance
Full RIPK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RIPK3 p.Val27Leu Uncertain significance Multiple submitters
- RIPK3 p.Ala56Glu Uncertain significance Single submitter
- RIPK3 p.Arg422Gly Uncertain significance Single submitter
- RIPK3 p.Asn238Ser Uncertain significance Single submitter
- RIPK3 p.Asp85Asn Uncertain significance Single submitter
- RIPK3 p.Gln107Leu Uncertain significance Single submitter
- RIPK3 p.Glu269Asp Uncertain significance Single submitter
- RIPK3 p.Glu356Lys Uncertain significance Single submitter
- RIPK3 p.Glu377Lys Uncertain significance Single submitter
- RIPK3 p.Gly100Val Uncertain significance Single submitter
- RIPK3 p.Gly173Arg Uncertain significance Single submitter
- RIPK3 p.Gly175Arg Uncertain significance Single submitter
- RIPK3 p.Gly323Arg Uncertain significance Single submitter
- RIPK3 p.Gly483Ser Uncertain significance Single submitter
- RIPK3 p.Gly487Ser Uncertain significance Single submitter
- RIPK3 p.Gly499Ser Uncertain significance Single submitter
- RIPK3 p.Gly517Arg Uncertain significance Single submitter
- RIPK3 p.Ile18Thr Uncertain significance Single submitter
- RIPK3 p.Leu150Pro Uncertain significance Single submitter
- RIPK3 p.Met344Leu Uncertain significance Single submitter
- RIPK3 p.Phe276Ser Uncertain significance Single submitter
- RIPK3 p.Pro12Arg Uncertain significance Single submitter
- RIPK3 p.Pro226Leu Uncertain significance Single submitter
- RIPK3 p.Pro318Arg Uncertain significance Single submitter
- RIPK3 p.Pro318Leu Uncertain significance Single submitter
- RIPK3 p.Pro395His Uncertain significance Single submitter
- RIPK3 p.Pro399Ser Uncertain significance Single submitter
- RIPK3 p.Pro439Leu Uncertain significance Single submitter
- RIPK3 p.Pro481Ser Uncertain significance Single submitter
- RIPK3 p.Ser170Leu Uncertain significance Single submitter
- RIPK3 p.Ser170Thr Uncertain significance Single submitter
- RIPK3 p.Ser372Asn Uncertain significance Single submitter
- RIPK3 p.Ser391Leu Uncertain significance Single submitter
- RIPK3 p.Thr384Lys Uncertain significance Single submitter
- RIPK3 p.Thr438Asn Uncertain significance Single submitter
- RIPK3 p.Thr476Ala Uncertain significance Single submitter
- RIPK3 p.Trp434Ser Uncertain significance Single submitter
- RIPK3 p.Trp512Gly Uncertain significance Single submitter
- RIPK3 p.Val229Met Uncertain significance Single submitter
- RIPK3 p.Val343Ala Uncertain significance Single submitter
- RIPK3 p.Val345Ala Uncertain significance Single submitter
- RIPK3 p.Val361Ala Uncertain significance Single submitter
- RIPK3 p.Val49Ala Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- RIPK3 p.Ala13Asp Uncertain significance Single submitter
- RIPK3 p.Ala201Thr Uncertain significance Single submitter
- RIPK3 p.Ala216Thr Uncertain significance Single submitter
- RIPK3 p.Arg141Gln Uncertain significance Single submitter
- RIPK3 p.Arg196Trp Uncertain significance Single submitter
- RIPK3 p.Arg239Gln Uncertain significance Single submitter
- RIPK3 p.Asn193Ile Uncertain significance Single submitter
- RIPK3 p.Asn454Ser Uncertain significance Single submitter
- RIPK3 p.Gly249Arg Uncertain significance Single submitter
- RIPK3 p.Gly254Cys Uncertain significance Single submitter
- RIPK3 p.Leu121Met Uncertain significance Single submitter
- RIPK3 p.Leu126Phe Uncertain significance Single submitter
- RIPK3 p.Leu183Pro Likely benign Single submitter
- RIPK3 p.Pro113Ser Uncertain significance Single submitter
- RIPK3 p.Ser267Arg Uncertain significance Single submitter
- RIPK3 p.Val204Ile Conflicting Single submitter
- RIPK3 p.Val214Ala Uncertain significance Single submitter
- RIPK3 p.Val233Ala Uncertain significance Single submitter
All RIPK3 variants
Conflicting classifications of pathogenicity 1
- p.Val204Ile Single submitter ⚠
Likely benign 11
- p.Arg422Gln Single submitter
- p.Cys365Tyr Single submitter
- p.Gln39Arg Single submitter
- p.Gly177Arg Single submitter
- p.Leu183Pro Single submitter ⚠
- p.Pro366Leu Single submitter
- p.Pro380Leu Single submitter
- p.Ser320Pro Single submitter
- p.Thr403Pro Single submitter
- p.Val194Ile Single submitter
- p.Val460Ile Single submitter
Uncertain significance 59
- p.Val27Leu Multiple submitters ⚠
- p.Ala13Asp Single submitter ⚠
- p.Ala201Thr Single submitter ⚠
- p.Ala216Thr Single submitter ⚠
- p.Ala56Glu Single submitter ⚠
- p.Arg141Gln Single submitter ⚠
- p.Arg196Trp Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg422Gly Single submitter ⚠
- p.Asn193Ile Single submitter ⚠
- p.Asn238Ser Single submitter ⚠
- p.Asn454Ser Single submitter ⚠
- p.Asp85Asn Single submitter ⚠
- p.Gln107Leu Single submitter ⚠
- p.Glu269Asp Single submitter ⚠
- p.Glu356Lys Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Gly100Val Single submitter ⚠
- p.Gly173Arg Single submitter ⚠
- p.Gly175Arg Single submitter ⚠
- p.Gly249Arg Single submitter ⚠
- p.Gly254Cys Single submitter ⚠
- p.Gly323Arg Single submitter ⚠
- p.Gly483Ser Single submitter ⚠
- p.Gly487Ser Single submitter ⚠
- p.Gly499Ser Single submitter ⚠
- p.Gly517Arg Single submitter ⚠
- p.Ile18Thr Single submitter ⚠
- p.Leu121Met Single submitter ⚠
- p.Leu126Phe Single submitter ⚠
- p.Leu150Pro Single submitter ⚠
- p.Met344Leu Single submitter ⚠
- p.Phe276Ser Single submitter ⚠
- p.Pro113Ser Single submitter ⚠
- p.Pro12Arg Single submitter ⚠
- p.Pro226Leu Single submitter ⚠
- p.Pro318Arg Single submitter ⚠
- p.Pro318Leu Single submitter ⚠
- p.Pro395His Single submitter ⚠
- p.Pro399Ser Single submitter ⚠
- p.Pro439Leu Single submitter ⚠
- p.Pro481Ser Single submitter ⚠
- p.Ser170Leu Single submitter ⚠
- p.Ser170Thr Single submitter ⚠
- p.Ser267Arg Single submitter ⚠
- p.Ser372Asn Single submitter ⚠
- p.Ser391Leu Single submitter ⚠
- p.Thr384Lys Single submitter ⚠
- p.Thr438Asn Single submitter ⚠
- p.Thr476Ala Single submitter ⚠
- p.Trp434Ser Single submitter ⚠
- p.Trp512Gly Single submitter ⚠
- p.Val214Ala Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val233Ala Single submitter ⚠
- p.Val343Ala Single submitter ⚠
- p.Val345Ala Single submitter ⚠
- p.Val361Ala Single submitter ⚠
- p.Val49Ala Single submitter ⚠