RNASE3 — 27 ClinVar variants
All ClinVar germline RNASE3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
7 Likely benign · 20 Uncertain significance
Full RNASE3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RNASE3 p.Ala35Thr Uncertain significance Single submitter
- RNASE3 p.Ala76Thr Uncertain significance Single submitter
- RNASE3 p.Ala76Val Uncertain significance Single submitter
- RNASE3 p.Arg100Gln Uncertain significance Single submitter
- RNASE3 p.Glu22Lys Uncertain significance Single submitter
- RNASE3 p.Gly20Ala Uncertain significance Single submitter
- RNASE3 p.Leu95His Uncertain significance Single submitter
- RNASE3 p.Met19Ile Uncertain significance Single submitter
- RNASE3 p.Pro48Ala Uncertain significance Single submitter
- RNASE3 p.Ser121Pro Uncertain significance Single submitter
- RNASE3 p.Ser86Arg Uncertain significance Single submitter
- RNASE3 p.Thr158Ile Uncertain significance Single submitter
- RNASE3 p.Val151Leu Uncertain significance Single submitter
- RNASE3 p.Val154Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- RNASE3 p.Arg104Trp Uncertain significance Single submitter
- RNASE3 p.Arg55Trp Uncertain significance Single submitter
- RNASE3 p.Arg72Cys Likely benign Single submitter
- RNASE3 p.Arg88His Uncertain significance Single submitter
- RNASE3 p.Thr33Met Uncertain significance Single submitter
- RNASE3 p.Val81Phe Uncertain significance Single submitter
All RNASE3 variants
Likely benign 7
- p.Arg148Gln Single submitter
- p.Arg72Cys Single submitter ⚠
- p.Arg72His Single submitter
- p.Gly83Ser Single submitter
- p.Met19Leu Single submitter
- p.Pro47Ser Single submitter
- p.Trp62Arg Single submitter
Uncertain significance 20
- p.Ala35Thr Single submitter ⚠
- p.Ala76Thr Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Arg100Gln Single submitter ⚠
- p.Arg104Trp Single submitter ⚠
- p.Arg55Trp Single submitter ⚠
- p.Arg88His Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Gly20Ala Single submitter ⚠
- p.Leu95His Single submitter ⚠
- p.Met19Ile Single submitter ⚠
- p.Pro48Ala Single submitter ⚠
- p.Ser121Pro Single submitter ⚠
- p.Ser86Arg Single submitter ⚠
- p.Thr158Ile Single submitter ⚠
- p.Thr33Met Single submitter ⚠
- p.Val151Leu Single submitter ⚠
- p.Val154Leu Single submitter ⚠
- p.Val154Phe Single submitter
- p.Val81Phe Single submitter ⚠