RNF114 — 35 ClinVar variants
All ClinVar germline RNF114 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
3 Likely benign · 32 Uncertain significance
Full RNF114 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RNF114 p.Ala11Val Uncertain significance Single submitter
- RNF114 p.Ala15Thr Uncertain significance Single submitter
- RNF114 p.Ala189Thr Uncertain significance Single submitter
- RNF114 p.Ala18Val Uncertain significance Single submitter
- RNF114 p.Arg104Gln Uncertain significance Single submitter
- RNF114 p.Arg197His Uncertain significance Single submitter
- RNF114 p.Arg198Trp Uncertain significance Single submitter
- RNF114 p.Arg26Cys Uncertain significance Single submitter
- RNF114 p.Arg6Pro Uncertain significance Single submitter
- RNF114 p.Arg82Leu Uncertain significance Single submitter
- RNF114 p.Arg95Cys Uncertain significance Single submitter
- RNF114 p.Asn185Thr Uncertain significance Single submitter
- RNF114 p.Asp7Ala Uncertain significance Single submitter
- RNF114 p.Cys176Arg Uncertain significance Single submitter
- RNF114 p.Cys8Phe Uncertain significance Single submitter
- RNF114 p.Gln54Leu Uncertain significance Single submitter
- RNF114 p.Gln5Arg Uncertain significance Single submitter
- RNF114 p.Gln5His Uncertain significance Single submitter
- RNF114 p.Gln5Pro Uncertain significance Single submitter
- RNF114 p.Glu37Asp Uncertain significance Single submitter
- RNF114 p.Met179Ile Uncertain significance Single submitter
- RNF114 p.Met217Ile Uncertain significance Single submitter
- RNF114 p.Pro147Leu Uncertain significance Single submitter
- RNF114 p.Pro17Leu Uncertain significance Single submitter
- RNF114 p.Pro23Leu Uncertain significance Single submitter
- RNF114 p.Pro62Ala Uncertain significance Single submitter
- RNF114 p.Pro73Leu Uncertain significance Single submitter
- RNF114 p.Val75Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All RNF114 variants
Likely benign 3
- p.Arg187His Single submitter
- p.Arg200Gln Single submitter
- p.Val78Met Single submitter
Uncertain significance 32
- p.Ala11Val Single submitter ⚠
- p.Ala15Thr Single submitter ⚠
- p.Ala189Thr Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg197His Single submitter ⚠
- p.Arg198Trp Single submitter ⚠
- p.Arg223Cys Single submitter
- p.Arg26Cys Single submitter ⚠
- p.Arg6Pro Single submitter ⚠
- p.Arg82Leu Single submitter ⚠
- p.Arg95Cys Single submitter ⚠
- p.Asn185Thr Single submitter ⚠
- p.Asp7Ala Single submitter ⚠
- p.Cys176Arg Single submitter ⚠
- p.Cys8Phe Single submitter ⚠
- p.Gln54Leu Single submitter ⚠
- p.Gln5Arg Single submitter ⚠
- p.Gln5His Single submitter ⚠
- p.Gln5Pro Single submitter ⚠
- p.Glu37Asp Single submitter ⚠
- p.Met179Ile Single submitter ⚠
- p.Met217Ile Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro62Ala Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Ser101Cys Single submitter ⚠
- p.Ser69Arg Single submitter ⚠
- p.Val172Phe Single submitter ⚠
- p.Val75Ile Single submitter ⚠