RNF133 — 51 ClinVar variants
All ClinVar germline RNF133 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
4 Likely benign · 47 Uncertain significance
Full RNF133 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RNF133 p.Ala203Thr Uncertain significance Single submitter
- RNF133 p.Ala343Thr Uncertain significance Single submitter
- RNF133 p.Arg217Lys Uncertain significance Single submitter
- RNF133 p.Arg221Gln Uncertain significance Single submitter
- RNF133 p.Asn312Ser Uncertain significance Single submitter
- RNF133 p.Asn89Asp Uncertain significance Single submitter
- RNF133 p.Asn89Ser Uncertain significance Single submitter
- RNF133 p.Asp229Asn Uncertain significance Single submitter
- RNF133 p.Asp246Glu Uncertain significance Single submitter
- RNF133 p.Asp371Asn Uncertain significance Single submitter
- RNF133 p.Cys214Ser Uncertain significance Single submitter
- RNF133 p.Cys259Trp Uncertain significance Single submitter
- RNF133 p.Gln231Glu Uncertain significance Single submitter
- RNF133 p.Glu244Gln Uncertain significance Single submitter
- RNF133 p.Glu55Gln Uncertain significance Single submitter
- RNF133 p.Gly63Val Uncertain significance Single submitter
- RNF133 p.His165Arg Uncertain significance Single submitter
- RNF133 p.Ile129Thr Uncertain significance Single submitter
- RNF133 p.Ile268Val Uncertain significance Single submitter
- RNF133 p.Ile283Val Uncertain significance Single submitter
- RNF133 p.Leu18Arg Uncertain significance Single submitter
- RNF133 p.Leu325Val Uncertain significance Single submitter
- RNF133 p.Lys96Glu Uncertain significance Single submitter
- RNF133 p.Met19Arg Uncertain significance Single submitter
- RNF133 p.Phe112Ile Uncertain significance Single submitter
- RNF133 p.Pro141Ser Uncertain significance Single submitter
- RNF133 p.Pro342Ala Uncertain significance Single submitter
- RNF133 p.Ser22Asn Uncertain significance Single submitter
- RNF133 p.Ser22Gly Uncertain significance Single submitter
- RNF133 p.Ser341Ala Uncertain significance Single submitter
- RNF133 p.Ser98Leu Uncertain significance Single submitter
- RNF133 p.Thr120Ile Uncertain significance Single submitter
- RNF133 p.Thr201Ala Uncertain significance Single submitter
- RNF133 p.Thr314Ala Uncertain significance Single submitter
- RNF133 p.Tyr190Cys Uncertain significance Single submitter
- RNF133 p.Tyr263Cys Uncertain significance Single submitter
- RNF133 p.Tyr41His Uncertain significance Single submitter
- RNF133 p.Val139Met Uncertain significance Single submitter
- RNF133 p.Val257Ile Uncertain significance Single submitter
- RNF133 p.Val48Phe Uncertain significance Single submitter
- RNF133 p.Val74Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- RNF133 p.Arg107Trp Uncertain significance Single submitter
- RNF133 p.Arg270Cys Uncertain significance Single submitter
- RNF133 p.Asn157Lys Uncertain significance Single submitter
- RNF133 p.Leu24Pro Uncertain significance Single submitter
- RNF133 p.Ser45Leu Uncertain significance Single submitter
- RNF133 p.Thr198Arg Uncertain significance Single submitter
All RNF133 variants
Likely benign 4
- p.Arg262His Single submitter
- p.Gly344Arg Single submitter
- p.Ile249Val Single submitter
- p.Thr120Ala Single submitter
Uncertain significance 47
- p.Ala203Thr Single submitter ⚠
- p.Ala343Thr Single submitter ⚠
- p.Arg107Trp Single submitter ⚠
- p.Arg217Lys Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Asn157Lys Single submitter ⚠
- p.Asn312Ser Single submitter ⚠
- p.Asn89Asp Single submitter ⚠
- p.Asn89Ser Single submitter ⚠
- p.Asp229Asn Single submitter ⚠
- p.Asp246Glu Single submitter ⚠
- p.Asp371Asn Single submitter ⚠
- p.Cys214Ser Single submitter ⚠
- p.Cys259Trp Single submitter ⚠
- p.Gln231Glu Single submitter ⚠
- p.Glu244Gln Single submitter ⚠
- p.Glu55Gln Single submitter ⚠
- p.Gly63Val Single submitter ⚠
- p.His165Arg Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Ile268Val Single submitter ⚠
- p.Ile283Val Single submitter ⚠
- p.Leu18Arg Single submitter ⚠
- p.Leu24Pro Single submitter ⚠
- p.Leu325Val Single submitter ⚠
- p.Lys96Glu Single submitter ⚠
- p.Met19Arg Single submitter ⚠
- p.Phe112Ile Single submitter ⚠
- p.Pro141Ser Single submitter ⚠
- p.Pro342Ala Single submitter ⚠
- p.Ser22Asn Single submitter ⚠
- p.Ser22Gly Single submitter ⚠
- p.Ser341Ala Single submitter ⚠
- p.Ser45Leu Single submitter ⚠
- p.Ser98Leu Single submitter ⚠
- p.Thr120Ile Single submitter ⚠
- p.Thr198Arg Single submitter ⚠
- p.Thr201Ala Single submitter ⚠
- p.Thr314Ala Single submitter ⚠
- p.Tyr190Cys Single submitter ⚠
- p.Tyr263Cys Single submitter ⚠
- p.Tyr41His Single submitter ⚠
- p.Val139Met Single submitter ⚠
- p.Val257Ile Single submitter ⚠
- p.Val48Phe Single submitter ⚠
- p.Val74Ile Single submitter ⚠