Sugi Variant

Sugi Variant/RNF168

RNF168 — 382 ClinVar variants

All ClinVar germline RNF168 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 182 flagged for review →

22 Pathogenic · 4 Pathogenic/Likely pathogenic · 8 Likely pathogenic · 11 Conflicting · 13 Benign · 5 Benign/Likely benign · 137 Likely benign · 182 Uncertain significance

Full RNF168 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 182

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 11

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 110

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 61

The independent predictors disagree with each other — read with care.

All RNF168 variants

Pathogenic 22

Pathogenic/Likely pathogenic 4

Likely pathogenic 8

Conflicting classifications of pathogenicity 11

Benign 13

Benign/Likely benign 5

Likely benign 137

Uncertain significance 182