RNF4 — 37 ClinVar variants
All ClinVar germline RNF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
7 Likely benign · 30 Uncertain significance
Full RNF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RNF4 p.Ala16Val Uncertain significance Single submitter
- RNF4 p.Arg102Lys Uncertain significance Single submitter
- RNF4 p.Arg147His Uncertain significance Single submitter
- RNF4 p.Arg164Cys Uncertain significance Single submitter
- RNF4 p.Arg6His Uncertain significance Single submitter
- RNF4 p.Arg78Ser Uncertain significance Single submitter
- RNF4 p.Arg81Ser Uncertain significance Single submitter
- RNF4 p.Asn115His Uncertain significance Single submitter
- RNF4 p.Asn169Ser Uncertain significance Single submitter
- RNF4 p.Asn181Ser Uncertain significance Single submitter
- RNF4 p.Asp44Gly Uncertain significance Single submitter
- RNF4 p.Asp97Asn Uncertain significance Single submitter
- RNF4 p.Cys51Gly Uncertain significance Single submitter
- RNF4 p.Glu99Val Uncertain significance Single submitter
- RNF4 p.Gly123Asp Uncertain significance Single submitter
- RNF4 p.Gly138Ala Uncertain significance Single submitter
- RNF4 p.His87Arg Uncertain significance Single submitter
- RNF4 p.Ile36Val Uncertain significance Single submitter
- RNF4 p.Leu31Val Uncertain significance Single submitter
- RNF4 p.Leu54Ser Uncertain significance Single submitter
- RNF4 p.Ser25Phe Uncertain significance Single submitter
- RNF4 p.Thr122Ile Uncertain significance Single submitter
- RNF4 p.Thr175Ser Uncertain significance Single submitter
- RNF4 p.Thr24Pro Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- RNF4 p.Arg19Gln Uncertain significance Single submitter
- RNF4 p.Arg6Cys Uncertain significance Single submitter
- RNF4 p.Arg78Lys Uncertain significance Single submitter
- RNF4 p.Cys51Arg Uncertain significance Single submitter
- RNF4 p.His182Tyr Uncertain significance Single submitter
- RNF4 p.Ile188Val Uncertain significance Single submitter
All RNF4 variants
Likely benign 7
- p.Ala116Thr Single submitter
- p.Asn145= Single submitter
- p.His156= Single submitter
- p.Ile11Val Single submitter
- p.Ser131= Single submitter
- p.Thr129= Single submitter
- p.Thr24Ala Single submitter
Uncertain significance 30
- p.Ala16Val Single submitter ⚠
- p.Arg102Lys Single submitter ⚠
- p.Arg147His Single submitter ⚠
- p.Arg164Cys Single submitter ⚠
- p.Arg19Gln Single submitter ⚠
- p.Arg6Cys Single submitter ⚠
- p.Arg6His Single submitter ⚠
- p.Arg78Lys Single submitter ⚠
- p.Arg78Ser Single submitter ⚠
- p.Arg81Ser Single submitter ⚠
- p.Asn115His Single submitter ⚠
- p.Asn169Ser Single submitter ⚠
- p.Asn181Ser Single submitter ⚠
- p.Asp44Gly Single submitter ⚠
- p.Asp97Asn Single submitter ⚠
- p.Cys51Arg Single submitter ⚠
- p.Cys51Gly Single submitter ⚠
- p.Glu99Val Single submitter ⚠
- p.Gly123Asp Single submitter ⚠
- p.Gly138Ala Single submitter ⚠
- p.His182Tyr Single submitter ⚠
- p.His87Arg Single submitter ⚠
- p.Ile188Val Single submitter ⚠
- p.Ile36Val Single submitter ⚠
- p.Leu31Val Single submitter ⚠
- p.Leu54Ser Single submitter ⚠
- p.Ser25Phe Single submitter ⚠
- p.Thr122Ile Single submitter ⚠
- p.Thr175Ser Single submitter ⚠
- p.Thr24Pro Single submitter ⚠